Asymmetric synthesis of polyols via transient hemiketals

通过瞬态半缩酮不对称合成多元醇

• 批准号: 512684257
• 负责人: Professor Dr. Johannes M. Wahl
• 金额: --
• 依托单位: Department Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/512684257?language=en
• 关键词: Asymmetric; synthesis; polyols; via; transient

In this project, polyolic structures will be built enantioselectively via the formation of a transient hemiketal from prochiral starting materials. Crucial for the formation of novel C-O bonds is the respective stability of the transient hemiketal, as well as its nucleophilicity, which will be investigated over the course of this project. Building on the acquired knowledge, we aim to explore catalysts to control the enantio- and diastereoselectivity of the newly formed C-O bonds, and to use the established molecular complexity in specific synthetic applications.

在该项目中，将通过由前手性起始材料形成瞬时半缩酮来对映选择性地构建多元醇结构。形成新型C-O键的关键是瞬态半缩酮的各自稳定性以及其亲核性，这将在本项目的过程中进行研究。基于所获得的知识，我们的目标是探索催化剂来控制新形成的C-O键的对映体和非对映体选择性，并在特定的合成应用中使用已建立的分子复杂性。