Self-assembled nanolayers of functionalised latexes as selective and adaptable nano-stationary phases in separation science

点击翻译按钮获取中文摘要

A new approach is proposed for the design and synthesis of functionalised ion-exchange stationary phases for analytical nano-separation methods. Desired charged functional groups are first affixed chemically onto nanometre sized latex particles and these particles are then self-assembled mechanically as monoloayer coatings onto a suitable supporting template such as fused silica, monolithic silica or polymer beds, microfibres or microtubes, and channels in microchips. The resultant coated surface then acts as a highly efficient ion-exchange stationary phase which will be used in a wide range of separation technologies including ion chromatography, capillary electrophoresis, capillary electrochromatography and solid-phase microextraction.