Towards a continuum model of orienting and defensive responses

定向(OR)和防御反应(DR)是注意意外刺激和避免伤害的重要生存功能的基础。我们将建立第一个人类OR/DR功能的综合图谱，使用同时记录大脑活动和身体的响应性。鉴于OR/DRS的性别和年龄差异，将对跨越60年的男性和女性进行研究。或/DR异常与注意力和压力的严重障碍有关，这些障碍也因性别和年龄而异。我们将研究OR/DR功能与健康个体对这些疾病的倾向性之间的关系。研究结果将为制定预防和干预战略提供框架。

Orienting (OR) and Defensive Responses (DR) underlie important survival functions of attending to unexpected stimuli and avoiding harm.We will establish the first integrative profile of human OR/DR function, using simultaneous recording of brain activity and 'body' responsivity. Given sex and age variation in OR/DRs, both males and females spanning six decades will be studied. OR/DR abnormalities are associated with major disorders of attention and stress, which also vary with sex and age. We will examine relationships between OR/DR function and proneness to these disorders in healthy individuals. The results will provide a framework for developing prevention and intervention strategies.