Development of integrated biological markers of brain function

脑功能综合生物标志物的开发

• 批准号: LP0455104
• 负责人: Prof Leanne Williams
• 金额: $ 44.3万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0455104
• 关键词: Development; integrated; biological; markers; brain

With the rapid growth of both brain imaging and genetics, we can now examine the biological basis of complex brain functions, such as memory. Our goal is to combine these techniques to develop evidence-based biological markers of normal function. These markers can then be used to screen for early signs of abnormal function (eg. in Alzheimer's disease) and to assess treatment effects. Two unique features ensure the project's feasibility: a) access to the first standardized, normative brain database (from the Brain Resource Company Ltd) and b) a scientific collaboration supporting the integration of brain imaging and genetics.

随着大脑成像和遗传学的快速发展，我们现在可以检查复杂大脑功能的生物学基础，例如记忆。我们的目标是将这些技术联合收割机开发以证据为基础的正常功能的生物标志物。这些标记物可以用于筛查功能异常的早期迹象（例如，在阿尔茨海默氏病中）并评估治疗效果。两个独特的功能确保了该项目的可行性：a）访问第一个标准化，规范化的大脑数据库（来自Brain Resource Company Ltd）和B）支持大脑成像和遗传学整合的科学合作。