Populationsgenetik von Helicobacter pylori

幽门螺杆菌的群体遗传学

• 批准号: 5151546
• 负责人: Professor Dr. Mark Achtman
• 金额: --
• 依托单位: Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 1999
• 资助国家: 德国
• 起止时间: 1998-12-31 至 2004-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5151546?language=en
• 关键词: Populationsgenetik; von; Helicobacter; pylori

The population genetics and geographical distribution of Helicobacter pylori will be investigated by multilocus sequence typing (MLST), i.e. sequencing multiple loci encoding housekeeping genes. Recent work from our laboratories has documented that this is a valid approach for these purposes and indicates that H. pylori isolated in East Asia (China, Japan) and Africa each belong to a distinct clonal grouping while bacteria from Europe, USA, and South America recombine so much that clonal descent cannot be recognized. These analyses will be extended to 500 bacteria from as diverse global sources as possible. The results will be the first comprehensive, global analysis of this kind for any bacterium and will supply the foundation for subsequent studies on the coevolution of H. pylori and human races.

将通过多位点序列分型（MLST）研究幽门螺杆菌的群体遗传学和地理分布，即对编码管家基因的多个位点进行测序。我们实验室最近的工作证明了这是一种有效的方法，并表明H。在东亚（中国、日本）和非洲分离的幽门螺杆菌各自属于不同的克隆群，而来自欧洲、美国和南美洲的细菌重组得如此之多，以至于不能识别克隆血统。这些分析将扩展到来自尽可能多样化的全球来源的500种细菌。该结果将是对任何细菌的第一次全面的全球性分析，并将为后续研究H。幽门螺杆菌和人类种族。