Multiscale stochastic modelling of genetic regulatory mechanisms

遗传调控机制的多尺度随机建模

• 批准号: DP0451696
• 负责人: Prof Kevin Burrage
• 金额: $ 14.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0451696
• 关键词: Multiscale; stochastic; modelling; genetic; regulatory

The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.

人类基因组的完成标志着一百年来细胞生物学中还原论科学的顶峰。虽然进一步的生物信息学分析将继续，重点是转向合成和了解调控遗传成分如何动态相互作用，形成功能表型。关键是理解随机性在细胞过程中的作用。该项目将探索这些角色，并将开发一个综合的复杂系统建模，模拟和可视化框架，用于探索和验证遗传调控模型。这将用于示例性应用，用于理解λ噬菌体中的诱导过程。