Sensor systems for real time ultra-sensitive monitoring of processes and interactions in the oral cavity (OralSens)

用于实时超灵敏监测口腔过程和相互作用的传感器系统 (OralSens)

• 批准号: 516793262
• 负责人: Professor Dr. Gianaurelio Cuniberti
• 金额: --
• 依托单位: Professur für Kariologie, Zahnhartsubstanzlehre und Endodontie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/516793262?language=en
• 关键词: Sensor; systems; real; time; ultra

A detailed understanding of bio-adhesion, bio-mineralization and metabolic processes in the oral cavity is of crucial importance in dental research. There are multiple interactions between oral fluids, the oral microbiota as well as soft and hard tissues. Many studies conducted research on metabolic processes based on end-point measurements of numerous parameters. However, there is still limited knowledge on the kinetics of important metabolites and ions within the oral cavity. Hence, the aim of the proposed project is the development of highly sensitive sensors for the continuous monitoring of clinically relevant organic and inorganic molecules within the oral cavity. This will allow deeper insight into the initiation and progression of oral diseases (e.g. erosion, caries, gingivitis, and periodontitis). Furthermore, this may offer new innovative options in the development of novel strategies in preventive dentistry.The oral cavity is an easily accessible clinical site for sensor technology. However, the complexity of oral fluids, instantaneous and ubiquitous protein adsorption processes as well as mechanical processes request for highly sophisticated adaptation of existing sensor technologies for the application within the oral cavity. We intend to develop miniaturized multi-sensor devices for the continuous measurement of glucose, lactate, pH, calcium, phosphate, and fluoride. These sensors will be adapted and elaborated for functionality within the oral cavity. For in situ applications, they will be mounted on individualized splints transmitting the measurements wirelessly via Bluetooth. The sensor application for continuous monitoring of the respective parameters according to alimentary and hygiene habits for many hours or ideally days is planned. On a longer-term perspective, sensors for additional parameters can be developed based on this research proposal. In future, such devices will be a valuable tool not only in basic research, but will also offer new perspectives towards personalized, non-invasive diagnostics in medicine and dentistry.

详细了解口腔内的生物粘附、生物矿化和代谢过程在牙科研究中至关重要。口腔液体、口腔微生物群以及软硬组织之间存在多种相互作用。许多研究都是基于对许多参数的终点测量来研究代谢过程的。然而，对口腔内重要代谢物和离子的动力学知识仍然有限。因此，该项目的目标是开发高灵敏度传感器，用于持续监测口腔内临床相关的有机和无机分子。这将使我们更深入地了解口腔疾病（如糜烂、龋齿、牙龈炎和牙周炎）的发生和发展。此外，这可能为预防性牙科的新策略的发展提供新的创新选择。口腔是传感器技术易于进入的临床部位。然而，口腔液体的复杂性、瞬时和无处不在的蛋白质吸附过程以及机械过程要求对现有传感器技术进行高度复杂的适应，以在口腔内应用。我们打算开发用于连续测量葡萄糖、乳酸、pH、钙、磷酸盐和氟化物的小型化多传感器设备。这些传感器将根据口腔内的功能进行调整和改进。对于现场应用，它们将安装在个性化的夹板上，通过蓝牙无线传输测量结果。根据饮食和卫生习惯，传感器应用可连续监测各参数数小时或理想情况下数天。从长远来看，可以根据本研究计划开发用于附加参数的传感器。未来，这样的设备不仅在基础研究中是一个有价值的工具，而且还将为医学和牙科的个性化、非侵入性诊断提供新的视角。