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Mental health across generations of Hispanic Americans: investigating the biomechanism of fetal programming

几代西班牙裔美国人的心理健康：调查胎儿编程的生物机制

基本信息

批准号：
10434786
负责人：
Kyle Steven Wiley
金额：
$ 6.76万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10434786
关键词：
Acculturation Address Adolescence Adult Affect Age-Months Alcohols Animal Model Back Behavioral Biochemical Biochemistry Biological Biological Assay Biological Markers Biology Biosocial Body mass index Brain Child Child Development Chronic Disease Corticotropin-Releasing Hormone Country Cues Data Data Collection Deterioration Development Dimensions Disadvantaged minority Discrimination Early identification Elderly Emotional Endocrine Physiology Endocrinology Environment Epidemiological trend Epidemiology Fetus Funding Generations Health Hispanic Hispanic Americans Human Hydrocortisone Immigrant Immigration Individual Infant Infant Behavior Infant Development Inflammation Inflammatory Interferon Type II Interleukin-10 Interleukin-6 Intervention Laboratories Learning Life Life Cycle Stages Life Experience Light Link Longitudinal Studies Longitudinal prospective study Maternal Age Measures Mediating Mediation Mental Health Mental disorders Methods Minority Minority Groups Minority Women Modeling Mothers Pattern Phenotype Physiological Physiology Plasma Policies Population Postpartum Period Predisposition Pregnancy Pregnancy Complications Pregnant Women Process Protocols documentation Psychoneuroimmunology Psychopathology Public Health Questionnaires Recording of previous events Regulatory T-Lymphocyte Research Research Domain Criteria Research Proposals Research Training Risk Sampling Signal Transduction Socioeconomic Status Statistical Data Interpretation Stress Temperament Testing Time Tobacco Toddler Training Trauma United States United States National Institutes of Health Woman base biopsychosocial cohort critical period experience fetal fetal programming illicit drug use immunoregulation infant temperament inflammatory marker innovation interest intergenerational life history neglect novel offspring perceived discrimination population based postnatal pregnant prenatal prenatal stress prepregnancy prevent preventive intervention prospective psychologic social social culture social vulnerability stressor study population therapy design transmission process trend unborn child

项目摘要

PROJECT SUMMARY/ABSTRACT Epidemiological evidence demonstrates increasing rates of mental illness across generations of Hispanic Americans. Because this trend occurs alongside improvements in socio-economic status across generations, it remains largely unknown why mental illness rates should increase with each subsequent generation post-immigration. Our proposal addresses this issue by suggesting a novel hypothesis based on the concept of fetal programming, i.e., the possibility that during pregnancy, maternal life experiences are reflected in biochemical signals that influence fetal developmental trajectories. We posit that immigration, discrimination, and acculturation-related stressors may, in the case of Hispanic immigrant women who become pregnant, alter intrauterine biochemistry in ways that affect offspring developmental trajectories that manifest in greater risks of psychopathologies. Previous studies have invoked the concept of fetal programming to account for effects of maternal prenatal stress on offspring mental health. However, the majority of these studies have been conducted with low- risk populations, and stressors related to ethnic and cultural minority status have been mostly neglected. Thus, there is a need to investigate the effects of maternal prenatal socio-cultural stress on child development in contexts of social vulnerabilities. The objective of the proposed research is to examine how maternal socio-cultural stressors are related to precursors of mental health risk among 12-month age infants via gestational stress physiology. This project utilizes the study population from the Mothers’ Cultural Experiences Study, an NIH-funded longitudinal, prospective study of Hispanic immigrant women followed across pregnancy and postpartum. The first research aim will investigate maternal stressors related to immigration and minority status in a context of social vulnerability and three domains of gestational stress physiology: endocrine stress, inflammation, and immunoregulation. The second research aim will investigate the effects of maternal socio-cultural stressors on two domains of infant development that have been associated with later life psychopathology risk: temperament and social-emotional development. The findings of this research will elucidate bio-social mechanisms that contribute to patterns of social vulnerability and mental illness among Hispanic Americans and may reveal opportunities for intervention that prevent intergenerational escalation of mental illness risks in this group. This research proposal is integrated with a training plan that includes learning and practicing primary data collection with pregnant women of minority status, conducting infant developmental assessments, laboratory methods in psychoneuroimmunology, and Hispanic cultural context of health. This research and training will prepare the PI to independently conduct innovative research on the biopsychosocial mechanisms that underlie intergenerational transmission of prenatal stress among disadvantaged, minority populations.

项目摘要/摘要流行病学证据表明，在几代拉美裔美国人中，精神疾病的发病率不断上升。由于这种趋势发生在几代人的社会经济地位改善的同时，它在很大程度上仍然是未知的。为什么精神疾病的发病率应该随着移民后的每一代人的增加而增加。我们的建议解决了这一问题通过提出一个基于胎儿编程概念的新假说，即在怀孕期间，母亲的生活经历反映在影响胎儿发育轨迹的生化信号中。我们假设移民、歧视和文化适应相关的压力源，对于成为怀孕，改变宫内生化，从而影响后代的发育轨迹，这些轨迹在更大的精神变态的风险。以前的研究已经引用了胎儿编程的概念来解释母体产前应激对子女心理健康的影响。然而，这些研究中的大多数都是在低- 风险人群以及与族裔和文化少数群体地位有关的压力源大多被忽视。因此，有一个需要调查母亲产前社会文化应激对儿童发展的影响漏洞。这项拟议的研究的目的是研究母亲的社会文化应激源如何与妊娠应激生理学对12个月龄婴儿心理健康风险的影响。该项目利用了美国国立卫生研究院资助的母亲文化体验研究中的研究人群对西班牙裔移民妇女的纵向前瞻性研究在怀孕和产后进行了跟踪调查。第一项研究 AIM将在社会脆弱性的背景下调查与移民和少数群体地位有关的产妇应激源妊娠应激生理学的三个领域：内分泌应激、炎症和免疫调节。第二项研究目的将调查母亲的社会文化压力对婴儿发展的两个领域的影响，这两个领域已经被与晚年生活有关的精神病理风险：气质和社会情绪发展。这项研究的发现研究将阐明导致社会脆弱性和精神疾病模式的生物-社会机制并可能揭示防止精神疾病代际升级的干预机会这一组中的风险。本研究计划与培训计划相结合，培训计划包括学习和练习主要数据收集与少数民族孕妇一起，进行婴儿发育评估，实验室方法心理神经免疫学和西班牙裔文化背景下的健康。这项研究和培训将为PI做好准备独立开展生物心理社会机制方面的创新研究，这些机制是代际传递的基础在弱势少数群体中存在着产前应激。