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Structure-Based Understanding of Diversity and Similarity of Cellular Motors

基于结构的对细胞电机多样性和相似性的理解

基本信息

批准号：
09279101
负责人：
SUTOH Kazuo
金额：
$ 81.02万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (A)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09279101/
关键词：
Molecular motors Myosin Nucleic acid motors Kinesin Dynein

项目摘要

This research was aimed at elucidating the characteristic functional properties of Motor proteins are involved in a variety of cellular processes such as cell locomotion, cell division, phagocytosis, endocytosis and vesicle transport. These motor proteins consist of three super-families ; myosin, kinesin and dynein. Although all of these proteins have the common function to change the chemical energy released by ATP hydrolysis to mechanical energy such as filament sliding and force, their in vitro and in vivo motor functions are surprisingly diverse. We have organized the reseairch project to understand the molecular mechanism of the diverse motor functions. To carry out the project, the following three research groups have been organized. (1) Searching for new motor proteins. (2) Dynamics of motor functions. (3) Single molecule imaging and manipulation. Besides these organized groups, individual researchers have been also recruited. To coordinate these researches, we have organized a meeting and a international conference each year. We have also devised various ways to enhance collaboration among the researchers in this project. This 4 year project has finally produced large number of important publications including many collaborative papers to which a number of members of this project have contributed.

本研究的目的是阐明马达蛋白的特征性功能特性，其参与多种细胞过程，如细胞运动、细胞分裂、吞噬、内吞和囊泡运输。这些马达蛋白由三个超家族组成：肌球蛋白、驱动蛋白和动力蛋白。虽然所有这些蛋白质都具有将ATP水解释放的化学能转化为机械能（如细丝滑动和力）的共同功能，但它们在体外和体内的运动功能惊人地多样化。我们组织了研究项目，以了解不同运动功能的分子机制。为实施该项目，组织了以下三个研究小组。(1)寻找新的马达蛋白。(2)运动功能的动力学。(3)单分子成像和操作。除了这些有组织的团体外，还招募了个人研究人员。为了协调这些研究，我们每年组织一次会议和一次国际会议。我们还设计了各种方法来加强研究人员之间在这个项目中的合作。这个为期4年的项目最终产生了大量的重要出版物，包括许多合作论文，其中一些成员的这个项目作出了贡献。