权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Molecular Mechanism of Atherosclerosis

动脉粥样硬化的分子机制

基本信息

批准号：
09281103
负责人：
KITA Toru
金额：
$ 128.06万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (A)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09281103/
关键词：
Atherosclerosis Vascular endothelial cell Vasculogenesis Angiogenesis Vascular smooth muscle cell Phenotypic conversion Adhesion molecule Oxidized LDL リゾフォスファチジルコリン CD36 LOX-1 マクロファージずり応力酸化LDL受容体

项目摘要

The Grants-in-Aid for Scientific Research on Priority Areas No. 09281104 was issued from 1997 to 2000. During the period, we organized a research group with scientists who are considered to be most active in the research field. Atherosclerosis is correlated with a variety of vascular disorders such as coronary heart disease. We therefore placed our goal on elucidation of the molecular mechanism of atherosclerosis and exploration of novel therapeutic strategies. To conduct investigation, the members were divided into 3 subgroups, i.e. Group 1, 2, and 3 with different subject of study as follows. We also formed a Central Committee to coordinate and facilitate the research activity of the subgroups.The Study Group 3 studied endothelial dysfunction and blood cells. There has been accumulating evidence that atherosclerosis is initiated by endothelial dysfunction due to a variety of biological insults. We therefore formed this subgroup to explore the key molecules involved in those events. We discovered novel scavenger receptors such as LOX-1 and SRPSOX. Furthermore, we revealed that adipose tissues produce cytokines abundantly. Among those cytokines, adiponectin has been shown to play an important role in atherogenesis and insulin resistance.In conclusion, we have made a successful progress in atherosclerosis research, which will be translated into clinical application in the near future.

1997年至2000年发放了第09281104号优先领域科学研究补助金。在此期间，我们组织了一个研究小组，其中包括被认为在研究领域最活跃的科学家。动脉粥样硬化与各种血管疾病如冠心病有关。因此，我们的目标是阐明动脉粥样硬化的分子机制和探索新的治疗策略。为了进行调查，将成员分为3个亚组，即第1、2和3组，研究主题如下。我们还成立了一个中央委员会来协调和促进各小组的研究活动。第3研究组研究内皮功能障碍和血细胞。越来越多的证据表明，动脉粥样硬化是由各种生物损伤引起的内皮功能障碍引起的。因此，我们成立了这个小组来探索参与这些事件的关键分子。我们发现了新的清道夫受体，如LOX-1和SRPSOX。此外，我们发现，脂肪组织产生大量的细胞因子。其中脂联素在动脉粥样硬化的形成和胰岛素抵抗中起着重要作用，在动脉粥样硬化的研究中取得了一定的进展，有望应用于临床。