Physiological and Biochemical Study of Gastrointestinal Functions.

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(1) When rats were fed an orotic acid diet, liver lipid level of rats fed a diet containing casein was significantly higher than that of a diet containing egg protein or soybean protein. The addition of an orotic acid to a diet containing casein caused to decrease liver superoxide dismutase activity, to increase serum ornithine carbamoyl transferase activity, to increase the hepatic concentration of 1,2-diacylglycerol. Liver damage by administration of an orotic acid might be due to the increased concentration of 1,2-diaclglycerol and decreased activity of hepatic superoxide dismutase.(2) 9-Oxooctadeca 10,12-dienoic acid as acetyl CoA carboxylase inhibitor from red pepper was found. Its activity was 50 fold higher as compared with the normal fatty acids.(3) Dietary beet fiber had a role to supprees the formation of the aberrant crypt foci induced by 1,2-dimethylhydrazine. Furthermore, it was found that the formation of the aberrant crypt foci induced by nu -ray irradiation was suppressed by the injection of anti-asialo GMI, but not by the addition of beet fiber.(4) Apoptosis and p53 level in epithelial cell of colon was induced by the administration of 1,2-dimethylhydrazine. Further observation was increased level of activin mRNA in colon. This is the first finding that activin is a factor to stop the cell cycle in apoptosis.