The mechanism for the hypercholesterolemia induced by amino acids

氨基酸引起高胆固醇血症的机制

• 批准号: 02660085
• 负责人: AOYAMA Yoritaka
• 金额: $ 1.28万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02660085/
• 关键词: Histidine; Hypercholesterolemia; HMG-CoA reductase; Cholesterol 7alpha-hydroxylase; Corticosterone; 銅欠乏

The mechanism for the hypercholesterolemia induced by excess dietary histidine was investigated in rats. The in vivo cholesterogenesis in the liver increased. Both the active and total activities of liver HMG-CoA reductase that is rate limiting step were significantly increased when rats were fed the histidine-excess diet. Furthermore, HMG-CoA reductase mRNA in the liver was also elevated. Whereas, hepatic cholesterol 7alpha-hydroxylase which is the rate limiting for the cholesterol degradation was not affected by the histidine-excess diet. Thus, the increased synthesis of cholesterol in the liver might be responsible for the hypercholesterolemia.Feeding of the histidine-excess diet caused the stimulation in the corticosterone in the serum. Therefore, the increased corticosterone might induce the hypercholesterolemia.

探讨了饮食过量组氨酸引起大鼠高胆固醇血症的机制。体内肝脏胆固醇生成增加。高组氨酸饮食大鼠肝脏HMG-CoA还原酶即限速步骤的活性和总活性均显着升高。此外，肝组织中HMG-CoA还原酶基因的表达也升高。而胆固醇降解的限速酶--肝胆固醇7α-羟基酶不受过量组氨酸饮食的影响。因此，肝脏中胆固醇合成的增加可能是高胆固醇血症的原因。摄取过量组氨酸的饮食会刺激血清中的皮质酮。因此，皮质酮升高可能导致高胆固醇血症。

项目成果

Aoyama Yoritaka: "Effect of excess histidine and copper intake on the metabolism of lipids and minerals in rats." Journal of Trace Elements in Experimental Medicine. 3(3). 209-217 (1990)

Aoyama Yoritaka：“过量组氨酸和铜摄入对大鼠脂质和矿物质代谢的影响。”

Aoyama Yoritaka: "Effects of dietary supplement of excess histidine on liver lipids and serum cholesterol in rats fed diets varying in casein levels and protein quality." Nutrition Reports International. 39(6). 1183-1193 (1989)

Aoyama Yoritaka：“饮食中添加过量组氨酸对饲喂不同酪蛋白水平和蛋白质质量的饮食的大鼠的肝脂质和血清胆固醇的影响。”

Aoyama Yoritaka: "Effect of dietary excess histidine and varying levels of copper on the metabolism of lipids and minerals in rats." Bioscience,Biotechnology,and Biochemistry. 56. 335-337 (1992)

Aoyama Yoritaka：“饮食中过量的组氨酸和不同水平的铜对大鼠脂质和矿物质代谢的影响。”

N.HISANAGA: "Potassium metabolism in rats refed a lysineーexcess diet after starvation" Agric.Biol.Chem.54. 1137-1142 (1990)

N.HISANAGA：“饥饿后摄入过量赖氨酸饮食的大鼠的钾代谢”Agric.Biol.Chem.54 1137-1142 (1990)。

Aoyama Yoritaka: "Effect of a dietary excess histidine and varying levels of copper on the metabolism of lipids and minerals in rats." Bioscience,Biotechnology,and Biochemistry. 56. 335-337 (1992)

Aoyama Yoritaka：“饮食中过量的组氨酸和不同水平的铜对大鼠脂质和矿物质代谢的影响。”