The mechanism for the hypercholesterolemia induced by amino acids

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The mechanism for the hypercholesterolemia induced by excess dietary histidine was investigated in rats. The in vivo cholesterogenesis in the liver increased. Both the active and total activities of liver HMG-CoA reductase that is rate limiting step were significantly increased when rats were fed the histidine-excess diet. Furthermore, HMG-CoA reductase mRNA in the liver was also elevated. Whereas, hepatic cholesterol 7alpha-hydroxylase which is the rate limiting for the cholesterol degradation was not affected by the histidine-excess diet. Thus, the increased synthesis of cholesterol in the liver might be responsible for the hypercholesterolemia.Feeding of the histidine-excess diet caused the stimulation in the corticosterone in the serum. Therefore, the increased corticosterone might induce the hypercholesterolemia.