Prediction of durability of artificial organs using an accerelated fatigue tester

使用加速相关疲劳测试仪预测人造器官的耐久性

基本信息

  • 批准号:
    09470288
  • 负责人:
  • 金额:
    $ 9.79万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1999
  • 项目状态:
    已结题

项目摘要

In order to predict a durability of heart valve prostheses, two types of commercially available (ISU-Standard) accerelated fatigue tests were employed, while improving a life time of Jellyfish polymer valve.A chronic animal experiment of Jellyfish valves incorporated into conventional sac-type blood pumps for over 300days exhibited that there were a fracture and calcification on this flexible membrane. Therefore, a long durability (approx. 1 year guarantee) of Jellyfish valve has been developing. while clearing a cause of the problems.First of all, design improvement of Jellyfish valve was attempted. Results of finite element analysis during closed phase of Jellyfish valve indicated that mechanical strain generated on valve membrane fracture and calcification in the animal experiment. Moreover further analysis suggested that an additional circular rim located at 7.0mm in radius was quite effective to avoid strain concentration. In vitro steady and pulsatile tests demonstrated that a modified valve with 0.5mm width rim located at 70mm in radius had a comparable hydrodynamic performance to the original Jellyfish valve.For the next step, commercially available two types of accelerated fatigue tests were employed. Fatigue tests successfully revealed that a durability of the modified valve was much more extended than the original Jellyfish valve by 7 times.Thus, chronic animal experiment with conventional sac-type blood pumps in which the modified valves were incorporated was performed for months. Hemolysis related to the application of the modified valve was not observed. This would be owing to the tapered configuration of the additional rim with 0.1mm width of inflow side.From the data above, the modified polymer valve showed great promise for clinical artificial heart application, and it was also clarified that our prevent fatigue tester could provide comparative durability data of polymer valves.
为了预测心脏瓣膜假体的耐久性,采用两种类型的市售(ISU-Standard)加速相关疲劳测试,同时提高Jellyfish聚合物瓣膜的寿命。将Jellyfish瓣膜并入常规囊型血泵中超过300天的慢性动物实验表明,该柔性膜上存在断裂和钙化。因此,长时间的耐用性(大约)。Jellyfish阀门的保修期为1年。首先,对Jellyfish阀进行了设计改进尝试。对Jellyfish瓣关闭期的有限元分析结果表明,在动物实验中,瓣膜产生了机械应变,导致瓣膜断裂和钙化。进一步的分析表明,在半径为7.0mm处设置一个附加的圆环可以有效地避免应变集中。体外稳态和脉动试验结果表明,改进后的Jellyfish瓣膜具有与原Jellyfish瓣膜相当的流体动力学性能,改进后的Jellyfish瓣膜边缘宽度为0.5mm,半径为70 mm。疲劳试验成功地表明,改进后的瓣膜的耐久性比原来的Jellyfish瓣膜延长了7倍。因此,使用传统的囊型血泵进行了几个月的慢性动物实验,其中包括改进后的瓣膜。未观察到与应用改良瓣膜相关的溶血。这可能是由于流入侧宽度为0.1mm的附加边缘的锥形配置。从以上数据来看,改性聚合物瓣膜在临床人工心脏应用中显示出巨大的前景,同时也阐明了我们的防疲劳试验机可以提供聚合物瓣膜的比较耐久性数据。

项目成果

期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
長久大地,藤里俊哉,辻 隆之,梅津光生,大場謙吉: "ポリウレタン製人工弁閉鎖不全の温度変化による影響" 第20回日本バイオレオロジー学会. 年会抄録集. 46 (1997)
Daichi Nagahisa、Toshiya Fujisato、Takayuki Tsuji、Mitsuo Umezu、Kenkichi Ohba:“温度变化对聚氨酯人工瓣膜反流的影响”第 20 届日本生物流变学会年会摘要(1997 年)。
  • DOI:
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    0
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M.Umezu: "Development of a mechanical circulatory simulator to evaluate hemodynamics of artificial organs"9^<th> International Conference on Biomedical Engineering. 3(6). 153-155 (1997)
M.Umezu:“开发用于评估人造器官血流动力学的机械循环模拟器”第 9 届国际生物医学工程会议。
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    0
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K.Iwasaki, M.Umezu, et al.: "Development of a durable polymer valve based on finete element analysis"APCMBE, Proc.. 252 (1999)
K.Iwasaki、M.Umezu 等人:“基于精细元素分析的耐用聚合物阀门的开发”APCMBE,Proc.. 252 (1999)
  • DOI:
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  • 影响因子:
    0
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  • 通讯作者:
T.Fujimoto, M.Umezu, et al.: "Effects of cardiac function on an arterial vascular graft implantation"Artif Organs. 23(7). 685 (1999)
T.Fujimoto、M.Umezu 等人:“心脏功能对动脉血管移植物植入的影响”Artif Organs。
  • DOI:
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  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
岩崎清隆,梅津光生他: "医療用高分子材料の疲労が血液適合性に与える影響の検討" 第14回ライフサポート学会講演予稿集. 106-107 (1998)
Kiyotaka Iwasaki、Mitsuo Umezu 等人:“医用高分子材料的疲劳对血液相容性的影响的检查”第 14 届生命支持学会会议记录 106-107 (1998)。
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    0
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UMEZU Mitsuo其他文献

UMEZU Mitsuo的其他文献

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{{ truncateString('UMEZU Mitsuo', 18)}}的其他基金

Development of mock circulation systems for the evaluation of innovative medical devices
开发用于评估创新医疗器械的模拟循环系统
  • 批准号:
    15H03041
  • 财政年份:
    2015
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Establishment of support technology for the development of surgical training simulator
手术训练模拟器开发支撑技术的建立
  • 批准号:
    14370419
  • 财政年份:
    2002
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of flow behavior of blood-biomaterial interfaces
血液-生物材料界面的流动行为分析
  • 批准号:
    10044180
  • 财政年份:
    1998
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).
Development of a mock circulatory system as a supporting tool to propose the oprimal cardiac surgery
开发模拟循环系统作为提出原始心脏手术的支持工具
  • 批准号:
    09557112
  • 财政年份:
    1997
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of viscoelastic tubes similar to blood pump
类似血泵的粘弹性管的研制
  • 批准号:
    07044167
  • 财政年份:
    1995
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for international Scientific Research
Development of a Internationally acceptable fatigue test system for prosthetic heart valve
开发国际认可的人工心脏瓣膜疲劳测试系统
  • 批准号:
    06557073
  • 财政年份:
    1994
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Developed of spiral vortex-type artificial heart
开发出螺旋涡流式人工心脏
  • 批准号:
    03044137
  • 财政年份:
    1991
  • 资助金额:
    $ 9.79万
  • 项目类别:
    Grant-in-Aid for international Scientific Research

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  • 批准号:
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  • 财政年份:
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