Development of a mock circulatory system as a supporting tool to propose the oprimal cardiac surgery

开发模拟循环系统作为提出原始心脏手术的支持工具

• 批准号: 09557112
• 负责人: UMEZU Mitsuo
• 金额: $ 8.26万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09557112/
• 关键词: mock circulatory system; vascular prostheses; pressure-volume relationship; charactristic impedance; cardiac output; mechanical arterial system; arterial load; external cardiac work; 圧一容積関係; 一回拍出量; 動脈負荷; 左心室ポンプ; 拡張末期圧; 拡張機能; 収縮力; 血液循環モデル

An originally-designed mock circulatory system (MCS) has been developed in order to evaluate functions of several types of artificial organs for the surgical treatment of cardiovascular deseases. The features of the present MCS has a capability of exhibiting a practical simulation of hemodynamics in aortic vascular prostheses, and of having a mechanical feasibility of the natural left ventricular contraction by the computer-based control.As mechanical properties of arterial vascular grafts are different from those of elastic natural arteries, it can be speculated that the left ventricular afterload might be elevated after the graft implantation due to its low compliance. By switching blood flow to a bypass graft which was inserted in parallel with the natural descending aorta of dog, the characteristic impedance was elevated by 2.6 times, furthermore, the cardiac output was decreased by 14%, and the cardiac work calculated from the pressure-volume relationships in the left ventricle, was increased by 1.5 times. MCS was also employed to represent hemodynamic characteristics as well as to compare the data with those in animal experiments. When the flow was set to 4L/min in MCS by the mechanical driven pump, either characteristic impedance of the arterial system or external work of the left ventricular model was increased by 2.4 or 1.5 times, respectively. Thus, it was anticipated that the external cardiac work would be elevated by the increase of the arterial impedance after the graft implantation.

为了评估心血管疾病手术治疗中几种人工器官的功能，一种原始设计的模拟循环系统（MCS）已经被开发出来。本系统的特点是能够模拟主动脉血管假体中的血流动力学，并通过计算机控制具有左心室自然收缩的机械可行性。由于动脉血管移植物的力学性能不同于弹性天然动脉，推测其顺应性较低，可能导致移植物植入后左心室后负荷升高。通过将血流切换到与狗的自然降主动脉平行插入的旁路移植术，特征阻抗提高了2.6倍，心输出量减少了14%，根据左心室压力-容积关系计算的心功增加了1.5倍。MCS也被用来表示血流动力学特征，并与动物实验数据进行比较。当机械驱动泵将MCS的流量设置为4L/min时，左室模型动脉系统的特征阻抗和外功分别增加2.4倍和1.5倍。因此，可以预见，移植后动脉阻抗的增加会增加心脏外功。

项目成果

Y.Shirashi,T.Fujimoto and M.Umezu: "Effects of cardiac function on an arterial vascular graft implanation"Artif Organs. 23-7. 685 (1999)

Y.Shirashi、T.Fujimoto 和 M.Umezu：“心脏功能对动脉血管移植物植入的影响”Artif Organs。

M.Umezu: "Development of a mechanical circulatory simulator to evaluate hemodynamics of artificial organs"9^<th> International Conference on Biomedical Engineering. 3(6). 153-155 (1997)

M.Umezu：“开发用于评估人造器官血流动力学的机械循环模拟器”第 9 届国际生物医学工程会议。

T.Fujimoto, M.Umezu, et al.: "Effects of cardiac function on an arterial vascular graft implantation"Artif Organs. 23(7). 685 (1999)

T.Fujimoto、M.Umezu 等人：“心脏功能对动脉血管移植物植入的影响”Artif Organs。

Tetsuo FUJIMOTO, Yasutaka MAKI, Yasuyuki SHIRAISHI, Mitsuo UMEZU, Toshinosuke AKUTSU: "Estimation of Drag and Lift Coefficients of Monoleaflet Tilting Disk During Opening Phase Using a High Speed Video Camera" Artificial Organs. 20(9)、. 516 (1997)

Tetsuo FUJIMOTO、Yasutaka MAKI、Yasuyuki SHIRAISHI、Mitsuo UMEZU、Toshinosuke AKUTSU：“使用高速摄像机估计单叶倾斜盘在打开阶段的阻力和升力系数”人工器官 20(9), 516 (1997)。

梅津光生: "循環系シミュレータ"計測と制御. 38(5). 312-316 (1999)

Mitsuo Umezu：“循环系统模拟器”测量和控制 38(5) (1999)。