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Methods of imparting the Functional Gradient to Some Dental Adhesives

赋予某些牙科粘合剂功能梯度的方法

基本信息

批准号：
09557158
负责人：
NAZU Thakashi
金额：
$ 6.02万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Among dental adhesives and cements, glass-ionomer cements consist of polyacids and solid particles. It has been shown possible to impart them a functional gradinet by generating a compositional gradient in one direction. In the current study, a simplified system consisting of polyacrylic acid (PAA) and glass particles was employed to represent a glass-ionomer cement system. The sedimentation properties of glass particles with various size, as the model fillers, were investigated under the gravity by observing the change in the turbidity. Sedimentation velocity was mainly dependent on (1) the expansion of co-existing polymers in the media, (2) the concentration of polymers, (3) the size of the dispersed particles. Further invesigation of the mixing effects of the flliers of different type, the effects of ionic strength or viscosity, etc.will help to develope this study. Through these studies, it is highly expected to reveal how the sedimentation is formulated, which describes the compositonal gradient or a composition at all arbitrary point, as a function of time, filler size and so on. Another possible way of generating a compositoinal gradient, an electrophoresis of charged components concerned in the adhesive systems, is also to be examined.Subsidary findings are as follows.1) Fluorescent distance probe was effectively used to find out the conformation of PAA.2) Differential scanning calorimetry was useful in the investigation of adhesive-tooth protein interaction.3) Full-automatic titration system has been developed, which has potintial applicability to many aspects.Those extra findings will also help developing the study of dental materials.

在牙科粘合剂和粘固剂中，玻璃离子粘固剂由多酸和固体颗粒组成。它已被证明是可能的，赋予他们一个功能梯度在一个方向上产生的成分梯度。在本研究中，采用由聚丙烯酸（PAA）和玻璃颗粒组成的简化系统来代表玻璃离子粘固剂系统。以不同粒径的玻璃颗粒为模型填料，通过浊度的变化，研究了重力作用下玻璃颗粒的沉降性能。沉降速度主要取决于（1）共存聚合物在介质中的膨胀，（2）聚合物的浓度，（3）分散颗粒的大小。进一步研究不同类型飞片的混合效果、离子强度或粘度等的影响将有助于这一研究的发展。通过这些研究，人们高度期望揭示沉积是如何形成的，它描述了组成梯度或在所有任意点处的组成，作为时间、填料尺寸等的函数。产生组成梯度的另一种可能的方式，粘合剂系统中有关的带电组分的电泳，主要研究结果如下：1）荧光距离探针能有效地确定PAA的构象; 2）差示扫描量热法能有效地研究PAA与牙蛋白的相互作用; 3）全分子量热法能有效地研究PAA与牙蛋白的相互作用。自动滴定系统的研制，在许多方面具有潜在的应用价值，这些新发现也将有助于牙科材料研究的发展。