Comprehensive analysis of functional monomer in dental adhesives using molecular-level analysis technique and investigation of the most suitable composition of adhesives

据报道，10-MDP在应用时促进了树脂-羟基磷灰石界面自组装层的形成。首先，本研究表明，商品化的10-MDP粘结剂在人牙本质和树脂界面上也形成了两个10-MDP分子的自组装分层，并形成稳定的MDP-Ca盐，类似于10-MDP溶液。FIB-SEM的三维观察表明，MDP-Ca盐在界面处形成，并延伸到粘结剂(树脂)层。以MDP-Ca盐为粘结层模型制备胶粘剂，测试其性能，发现加入MDP-Ca盐后，聚合收缩减小，部分性能提高。结果表明，含MDP的胶粘剂确实在胶粘剂界面形成纳米层状结构，MDP-Ca盐在胶粘剂层中扩散。粘结层与树脂、盐和其他残留牙体物质的性质可能会影响粘附力。

It was reported that 10-MDP promoted formation of self-assembled layering at resin- hydroxyapatite interface when it was applied. Firstly, this study showed that the commercial 10-MDP based adhesives also formed the self-assembled layering of two 10-MDP molecules, joined by stable MDP-Ca salt formation, at the interface between human dentin and resin as similar to 10-MDP solution. The three-dimensional observation with FIB-SEM revealed that MDP-Ca salt was formed at the interface, extending into the adhesive (resin) layer. When we prepared adhesives containing MDP-Ca salts as a model of adhesion layer and measured its properties, polymerization shrinkage decreased and some of properties increased by adding the salt. It is concluded that MDP-containing adhesives do form nano-layering at the adhesive interface and MDP-Ca salt spread through the adhesive layer. The properties of adhesive layer with resin, salts and other residual tooth substances may influence the adhesion.