Clarification of the mechanisms of condylar resorption in osteoarthrosis and the therapcutic techniques

阐明骨关节病髁突吸收机制及治疗技术

• 批准号: 09557176
• 负责人: TANNE Kazuo
• 金额: $ 7.17万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09557176/
• 关键词: Temporomandibular joint; Osteoarthrosis (OA); Condylar resorption; Synovial fluid; Condylar cartilage; Mechanical loading; 顎関節内障; 顎関節病態; 下顎頭位; 顎関節負荷; 関節軟骨; 軟骨基質タンパク質

In this study, the mechanism of condylar resorption in osteoarthrosis (OA) was examined in association with craniofacial morphology, intra-articular pathologic status, and biochemical markers. First, the prevalence of QA in general population of young adults was examined, indicating a considerably high prevalence. Small and distally positioned mandible with vertical skeletal discrepancy was derived as morphologic features to subjects with OA.Furthermore, such morphologic characteristics were speculated to be related to lack in biomechanical equilibrium for TMJ loading. Finally, such biochemical factors as cartilage matrix protein (CMP) and pyridinoline/deoxypyridinoline ratio were significantly associated with the onset and/or progress of condylar deformity or resorption in OA, although the CMP was not detected in the synovial fluid.Based upon these findings, an integrated therapeutic system with orthodontic approach was applied to patients with OA, confirming an availability of the therapeutic system for deriving an adaptive response of the condyle and curing he condylar deformity.

在这项研究中，骨关节病（OA）髁突吸收的机制与颅面形态，关节内病理状态，和生化标志物进行了研究。首先，检查了QA在年轻成人的一般人群中的患病率，表明患病率相当高。骨性关节炎患者下颌骨的形态学特征是下颌骨小而远位，且垂直方向的骨骼差异。此外，这种形态学特征被推测与TMJ负荷的生物力学平衡缺乏有关。最后，虽然在关节液中未检测到软骨基质蛋白（CMP），但生化因子如软骨基质蛋白（CMP）和吡啶啉/脱氧吡啶啉比值与OA患者髁突畸形或吸收的发生和/或进展显著相关。确认治疗系统用于导出髁的适应性响应和治疗髁畸形的可用性。

项目成果

野々山大介,他: "顎変形症患者における顎関節病態と顎顔面形態との関連性" 日顎変形誌. 8. 57-66 (1998)

Daisuke Nonoyama 等人：“颌畸形患者颞下颌关节病理学与颌面形态之间的关系”Jaw Deformity 杂志 8. 57-66 (1998)。

Sasaki, A., Ozawa, A., Nonoyama, D., Tanne, K.: "Association between lateral shift of the mandibular and pathologic status of the TMJ" J.Chu-Shikoku Orthod.Society. 9. 34-39 (1997)

Sasaki, A.、Ozawa, A.、Nonoyama, D.、Tanne, K.：“下颌侧移与颞下颌关节病理状态之间的关联”J.Chu-Shikoku Orthod.Society。

谷本幸太郎、他: "顎関節疼痛を有する患者における尿中ビリジノリン、デオキシビリジノリンの定量" 日顎誌. (印刷中). (1999)

Kotaro Tanimoto 等人：“颞下颌关节疼痛患者尿中维啶啉和脱氧维啶啉的测定”Nipponjyo（出版中）。

Ozawa, S., Tanne K.: "Diagnostic accuracy of sagittal condylar movement patterns for identifying internal derangement of the temporomandibular joint" J.Orofac.Pain. 11. 222-231 (1997)

Ozawa, S., Tanne K.：“用于识别颞下颌关节内部紊乱的矢状髁运动模式的诊断准确性”J.Orofac.Pain。

Tanne, K.: "Differntial diagnosis and therapeutic cues for orthodontic patients with various stages of TMJ internal derangement" J.Taiwan Assoc.Orthod.9. 12-18 (1997)

Tanne, K.：“不同阶段颞下颌关节内部紊乱的正畸患者的鉴别诊断和治疗线索”J.Taiwan Assoc.Orthod.9。