Clarification of the mechanisms of condylar resorption in osteoarthrosis and the therapcutic techniques

在这项研究中，骨关节病（OA）的髁突吸收机制与颅面形态、关节内病理状态和生化指标的关系进行了研究。首先，研究了QA在普通青年人群中的患病率，表明患病率相当高。小而远端定位的下颌骨与垂直骨骼差异是OA患者的形态学特征。此外，这种形态特征被推测与TMJ加载时缺乏生物力学平衡有关。最后，软骨基质蛋白（CMP）和吡啶啉/脱氧吡啶啉比值等生化因子与骨性关节炎中髁突畸形或吸收的发生和/或进展显著相关，尽管在滑液中未检测到CMP。基于这些发现，我们将一套结合正畸入路的综合治疗系统应用于骨关节炎患者，证实了该治疗系统在髁突产生适应性反应和治疗髁突畸形方面的有效性。

In this study, the mechanism of condylar resorption in osteoarthrosis (OA) was examined in association with craniofacial morphology, intra-articular pathologic status, and biochemical markers. First, the prevalence of QA in general population of young adults was examined, indicating a considerably high prevalence. Small and distally positioned mandible with vertical skeletal discrepancy was derived as morphologic features to subjects with OA.Furthermore, such morphologic characteristics were speculated to be related to lack in biomechanical equilibrium for TMJ loading. Finally, such biochemical factors as cartilage matrix protein (CMP) and pyridinoline/deoxypyridinoline ratio were significantly associated with the onset and/or progress of condylar deformity or resorption in OA, although the CMP was not detected in the synovial fluid.Based upon these findings, an integrated therapeutic system with orthodontic approach was applied to patients with OA, confirming an availability of the therapeutic system for deriving an adaptive response of the condyle and curing he condylar deformity.