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Association of masticatory function with morphology and function of the central nervous system

咀嚼功能与中枢神经系统形态和功能的关联

基本信息

批准号：
09470471
负责人：
TANNE Kazuo
金额：
$ 8.13万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

In recent years, an important role of the tooth and the relevant functions such as biting, chewing and mastication has been addressed. Under such background, the present study was designed to investigate the influences of stomatognathic functions on the development of the other tissues and organs, the central nervous system in particular, by use of rats and mice as experimental animals and human subjects.In an experiment with osteopetrotic (op/op) mice involved with defects in osteoclastic activity and tooth eruption, the reduced masticatory function produced a decrease in the number of neurons in the central nervous system. Such phenomena were similarly observed in normal mice and rats subjected to artificial reduction in mechanical stimuli from mastication and physical exercise. These findings were eliminated to some extent, approaching the normal controls, by an artificial injection of osteoclast induction agents, which generate tooth eruption and recover in masticatory function. Furthermore, . mechanical stimuli to the teeth in rats induced a specific C-fos protein in the central nervous system. Meanwhile, such association in humans has been studied by use of a portable electromyogram recorder, demonstrating the nature of masticatory function in subjects with occiusal discrepancy. In conclusion, it is emphasized that external mechanical stimuli from stomatognathic functions substantially affect the development of the central nervous system, indicating an important role of the dentition and the related masticatory function.

近年来，牙齿的重要作用以及与之相关的咬合、咀嚼和咀嚼等功能已经得到了重视。在此背景下，本研究以大鼠和小鼠为实验动物和人为研究对象，探讨口颌功能对其他组织器官尤其是中枢神经系统发育的影响。在一项涉及破骨功能缺陷和牙齿萌出的实验中，咀嚼功能降低导致中枢神经系统神经元数量减少。类似的现象在正常小鼠和大鼠身上也观察到，这些小鼠和大鼠受到来自咀嚼和体育锻炼的机械刺激的人为减少。通过人工注射破骨细胞诱导剂，这些发现在一定程度上被消除，接近正常对照组，这些诱导剂会产生牙齿萌出并恢复咀嚼功能。此外，。对大鼠牙齿的机械刺激在中枢神经系统中诱导了一种特定的C-FOS蛋白。同时，使用便携式肌电记录仪对人类的这种联系进行了研究，证明了咬合不一致受试者的咀嚼功能的本质。综上所述，强调口腔颌面功能的外部机械刺激对中枢神经系统的发育有重要影响，表明牙列及其相关的咀嚼功能具有重要作用。