Synthesis of Pseudocyclophanes Bearing Multi-recognition Sites and the allosteric Control of Their Recognition Ability
具有多识别位点的拟环芳烷的合成及其识别能力的变构控制
基本信息
- 批准号:09640622
- 负责人:
- 金额:$ 1.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1998
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this study a new allosteric host was designed and synthesized. Allosteric host 1 consists of two 2,2'-bipyridine moieties, two bisphenol A skeletons, and an ammonium moiety. Host 1 binds a Cu(I) ion to give the corresponding tetrahedral complex, pseudocyclophane, which has a binding cavity and the ammonium group in close proximity. In solvent extraction, 1-Cu(I) complex showed a higher affinity toward flavin mononucleotide sodium salt (FMN) than 1. However, meaningful effect of Cu(I) is not found in a similar host, which does not have an ammonium moiety. These results strongly suggest that cooperative interactions between the cavity and the charged moiety of 1-Cu(I) are important for the FMN binding. After extraction of FMN with 1-Cu(I), the guest was moved to the aqueous phase again by the addition of bathocuproine or triethylamine hydrochloride. Bathocuproine strongly binds to Cu(I) to destroy 1-Cu(I) quantitatively. Triethylamine hydrochloride interacts with the guest to inhibit interaction between 1-Cu(I) and the phosphate moiety of the guest. These results indicated that the framework and the ammonium moiety of the pseudocyclophane are important for the recognition of the guest. In addition, the results show that on-and-off control of molecular recognition is achieved by using this system. A similar allosteric recognition of c-AMP was also performed successfully.We believe that this study provided a new and fundamental way to construct a sophisticated on-and-off system for recognition of complicated organic molecules in artificial systems.
本研究设计并合成了一种新的变构宿主。变构宿主1由两个2,2'-联吡啶部分,两个双酚A骨架和一个铵部分组成。宿主1结合一个Cu(I)离子生成相应的四面体配合物——伪环环烷,该配合物具有一个结合腔,紧邻铵基。溶剂萃取时,1- cu (I)配合物对黄素单核苷酸钠盐(FMN)的亲和力高于1- cu (I)配合物。然而,Cu(I)在没有铵基的类似宿主中没有明显的作用。这些结果强烈表明,空腔与1-Cu(I)的带电部分之间的协同相互作用对于FMN的结合是重要的。用1-Cu(I)萃取FMN后,再加入根碱或盐酸三乙胺将客体移至水相。Bathocuproine与Cu(I)强结合,定量破坏1-Cu(I)。盐酸三乙胺与客体相互作用,抑制1-Cu(I)与客体的磷酸盐部分之间的相互作用。这些结果表明,伪环环烷的结构和铵基部分对识别客体具有重要意义。此外,该系统还实现了分子识别的开关控制。c-AMP的类似变构识别也成功进行。我们相信本研究为构建复杂的开关系统来识别人工系统中的复杂有机分子提供了一种新的和基本的方法。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tatsuya Nabeshima: "On-and-off Control of Allosteric Affinity toward Flavin Mononuclectide by the Use of a Pseudo cyclophane Formed with Cu (I) as an Effector" J.Org.Chem・. 63. 2788-2789 (1998)
Tatsuya Nabeshima:“通过使用以 Cu (I) 作为效应物形成的伪环烷对黄素单核苷酸的变构亲和力进行断断续续的控制”J.Org.Chem·63. 2788-2789 (1998)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Tatsuya Nabeshima: "On-and-off Control of Allosteric Affinity toward Flavin Mononucleotide by the Use of a Pseudoeyclophane Formed with Cu(I) as an Effector" J.Org.Chem.63. 2788-2789 (1998)
Tatsuya Nabeshima:“使用以 Cu(I) 形成的伪环烷作为效应物对黄素单核苷酸的变构亲和力进行断断续续的控制”J.Org.Chem.63。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Tatsuya Nabeshima: "On-and-off Control of Allosteric Affinity toward Flavin Mononucleatide by the Use of a Pseudecyclophane Formed with Cu(I) as an Effecter" J.Org.Chem.63. 2788-2789 (1998)
Tatsuya Nabeshima:“使用以 Cu(I) 形成的伪环烷作为效应物对黄素单核苷酸的变构亲和力进行断断续续的控制”J.Org.Chem.63。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
鍋島達弥: "On-and-off Control of Allosteric Affinity toward Flavin Mononucleotide by the Use of a Pseudocyclophane Formed with Cu(I) as an Effector" J.Org.Chem.63(印刷中). (1998)
Tatsuya Nabeshima:“使用以 Cu(I) 形成的伪环烷作为效应物对黄素单核苷酸的变构亲和力进行断断续续的控制”J.Org.Chem.63(出版中)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
NABESHIMA Tatsuya其他文献
NABESHIMA Tatsuya的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('NABESHIMA Tatsuya', 18)}}的其他基金
Construction of Luminescent Molecules Bearing a Molecular Coat with On-Off Ability Responding Solvent Polarity
具有响应溶剂极性开关能力的分子涂层发光分子的构建
- 批准号:
26620127 - 财政年份:2014
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Synthesis and controllable structural interconversions of multidentate dipyrrin- typical element complexes
多齿二吡啉-典型元素配合物的合成及可控结构互变
- 批准号:
24350020 - 财政年份:2012
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Approach to Precise Modification of Graphene Surface by Metal Complexes for Properties Control
金属配合物对石墨烯表面进行精确改性以控制性能的方法
- 批准号:
24655114 - 财政年份:2012
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Construction of Function-accumulated Supramolecules by Controlling Flexible Structure on the Basis of Formation of Helical Pseudomacrocycles
基于螺旋拟大环形成的控制柔性结构构建功能积累型超分子
- 批准号:
20245029 - 财政年份:2008
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Construction and Molecular Recognition of Metallo-supramolecules and Their Responding Functions to External Stimulus
金属超分子的构建、分子识别及其对外界刺激的响应功能
- 批准号:
18064005 - 财政年份:2006
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Construction of Metallo-nano Architecture Possessing Cooperative Functions
具有协同功能的金属纳米结构的构建
- 批准号:
15350076 - 财政年份:2003
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
Molecular recognition and enantioselective reaction of amino acids
氨基酸的分子识别和对映选择性反应
- 批准号:
23K04668 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Ultimate Two-Stage Selection of Nucleic Acid Aptamers as Novel Molecular Recognition Elements
核酸适体作为新型分子识别元件的终极两阶段选择
- 批准号:
23K17982 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Development of a nanoplastic detection sensor utilizing DNA as molecular recognition elements.
开发利用 DNA 作为分子识别元件的纳米塑料检测传感器。
- 批准号:
23K18527 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Highly Sophisticated Molecular Recognition Systems Based on "Supramolecular Aptamers"
基于“超分子适体”的高度精密分子识别系统
- 批准号:
23K19262 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Molecular Recognition Glycopolymers by Controlled Polymerization and Development of Polymer Drugs
可控聚合的分子识别糖聚合物及高分子药物的开发
- 批准号:
23H02015 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development and Functionality Expansion of Highly Stable Multivalent Molecular Recognition Elements Based on Proteinaceous CutA1 Scaffold
基于蛋白质CutA1支架的高稳定多价分子识别元件的开发和功能扩展
- 批准号:
23K04508 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Directed Molecular Recognition through Next-Generation Hybrid Molecular Imprinting
通过下一代混合分子印迹进行定向分子识别
- 批准号:
EP/V046594/2 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Research Grant
Molecular recognition by ADAR1 of Z-RNA within transcriptomes
ADAR1 对转录组中 Z-RNA 的分子识别
- 批准号:
10712207 - 财政年份:2023
- 资助金额:
$ 1.15万 - 项目类别:
Development of computational models to understand the dynamic molecular recognition mechanisms of cannabinoid receptors
开发计算模型以了解大麻素受体的动态分子识别机制
- 批准号:
RGPIN-2021-03161 - 财政年份:2022
- 资助金额:
$ 1.15万 - 项目类别:
Discovery Grants Program - Individual
Mechanism of molecular recognition between intrinsically disordered regions.
本质上无序区域之间的分子识别机制。
- 批准号:
22K06101 - 财政年份:2022
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)