Radionuclide stent system aided for intravascular irradiation

辅助血管内照射的放射性核素支架系统

• 批准号: 09670923
• 负责人: TAKAHASHI Motoichiro
• 金额: $ 2.3万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670923/
• 关键词: Metallic Stent; Intimal Hyperplasia; 192Iridium; Intravascular Radiotherapy; 金属ステント; 内膜増殖; 血管内放射線治療; 密閉小線源治療; ステント; 血管内照射

Restenosis or occlusion with pseudointimal hyperplasia is a troublesome problem in stenting lumen including arteries or TIPS tract. In vitro, we investigated endovascular irradiation with a surface dose of l2Gy using an Iridium 192 sources, with special reference to Isodose curves of a iridium 192 ERAD in a curved vessel model. Using a newly developed the prototype double occlusion balloon catheter that enabled to place the flexible catheter induding iridium 192 sources in the center of the lumen, optimal isodose curves were obtained. Iridium 192-high dose rate radiotherapy was carried out for the 34 patients with tongue cancer. Endovascular stenting using Walistents or Meadox vascular stent graft was also made for the patients with tumor encasement, TIPS, atherosclerotic stenosis or aneurysm. These results suggest the clinical technical possibility of application of intravascular radiotherapy using this combination of a double balloon catheter and a flexible catheter including 192 Iridium sources. An experimental study is now made to evaluate the safety of the surrounding tissue of the irradiated vessel in addition to the vessel wall itself.

假性内膜增生引起的再狭窄或闭塞是包括动脉或TIPS管道在内的支架管腔中的一个棘手问题。在体外，我们研究了使用铱 192 源进行表面剂量为 12Gy 的血管内照射，特别参考弯曲血管模型中铱 192 ERAD 的等剂量曲线。使用新开发的原型双闭塞球囊导管，能够将包含铱 192 源的柔性导管放置在管腔中心，获得最佳等剂量曲线。对34例舌癌患者进行了铱192高剂量率放疗。还对肿瘤包绕、TIPS、动脉粥样硬化狭窄或动脉瘤患者进行了使用 Walistents 或 Meadox 血管支架移植的血管内支架植入术。这些结果表明使用双球囊导管和包含 192 个铱源的柔性导管的组合应用血管内放射治疗的临床技术可能性。现在正在进行一项实验研究，以评估除了血管壁本身之外，受照射血管周围组织的安全性。

项目成果

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Nishimura T.等人：“口腔舌癌间质高剂量率近距离放射治疗 J.Jpn.Soc.Ther.Radiol”。

Takahashi M.et al: "Endovascular treatment for venous occlusive diseases of the abdomen with special reference to Budd-Chiari Syndrome" IVR. 13 (2). 168-176 (1998)

Takahashi M.et al：“腹部静脉闭塞性疾病的血管内治疗，特别是布加综合征”IVR。

高橋元一郎: "IVRの適応と不適応について" 新医療. 24・5. 109-113 (1997)

高桥本一郎：《IVR 的适用性和不相容性》24・5（1997）。