Radionuclide stent system aided for intravascular irradiation

再狭窄或闭塞合并假性内膜增生是支架置入术中的一个棘手问题，包括动脉或尖端。在体外，我们研究了表面剂量为12GyIr-192的血管内照射，特别是参考了弯曲血管模型中Ir-192 ERAD的等剂量曲线。利用最新研制的双闭塞球囊导管样机，将含有Ir 192源的柔性导管放置在管腔中心，获得了最佳的等剂量曲线。对34例舌癌患者进行了Ir 192高剂量率放射治疗。对于肿瘤包被、TIPS、动脉粥样硬化性狭窄或动脉瘤的患者，也可使用Walistent或Meadox支架进行血管内支架植入术。这些结果提示使用双气囊导管和包括192个Ir源的柔性导管的组合进行血管内放射治疗的临床技术可能性。现在，除了评估血管壁本身之外，还进行了一项实验研究，以评估受辐射血管周围组织的安全性。

Restenosis or occlusion with pseudointimal hyperplasia is a troublesome problem in stenting lumen including arteries or TIPS tract. In vitro, we investigated endovascular irradiation with a surface dose of l2Gy using an Iridium 192 sources, with special reference to Isodose curves of a iridium 192 ERAD in a curved vessel model. Using a newly developed the prototype double occlusion balloon catheter that enabled to place the flexible catheter induding iridium 192 sources in the center of the lumen, optimal isodose curves were obtained. Iridium 192-high dose rate radiotherapy was carried out for the 34 patients with tongue cancer. Endovascular stenting using Walistents or Meadox vascular stent graft was also made for the patients with tumor encasement, TIPS, atherosclerotic stenosis or aneurysm. These results suggest the clinical technical possibility of application of intravascular radiotherapy using this combination of a double balloon catheter and a flexible catheter including 192 Iridium sources. An experimental study is now made to evaluate the safety of the surrounding tissue of the irradiated vessel in addition to the vessel wall itself.