Corrosion Fatigue Resistant and Intimal Hyperplasia Suppressive Biometal for Bioabsorbable Stents
用于生物可吸收支架的抗腐蚀疲劳和内膜增生抑制生物金属
基本信息
- 批准号:9816239
- 负责人:
- 金额:$ 36.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-06-15 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAbsorbable ImplantsAddressAgeAlloysAnti-inflammatoryAortaArteriesBehaviorBenchmarkingBiodegradationBlood VesselsCellsCharacteristicsChronicComplexCoronaryCorrosionDefectDeveloped CountriesDeveloping CountriesDietDropsElementsEndotheliumEngineeringEnsureEnvironmentExhibitsFailureFatigueFormulationFractureGrainHealthHeart DiseasesHumanHyperplasiaIndividualIndustrializationInflammatoryInflammatory ResponseIronLaboratoriesLocationMagnesiumMechanicsMetabolic Clearance RateMetalsModelingObesityOxidesPatientsPerformancePeriodicityPhasePhysiologicalPilot ProjectsPlasmaPrecipitationProceduresPropertyRattusResearchResistanceRiskSolubilityStainless SteelStentsStressSystemTemperatureTestingTextureThickTimeToxic effectTrace ElementsWorkZincbasebiomaterial compatibilitycardiovascular healthdensitydesignductileexperiencefallsimprovedin vivointerestmechanical loadmechanical propertiesmetallicitynovelparticleprototyperesponsescaffoldside effect
项目摘要
Summary
Heart disease is of great societal interest due to its drastic impact on health in industrialized
nations, especially in developed countries where obesity rates are high and the typical diet is
not conducive to cardiovascular health. While invasive procedures are not desirable, they are
often crucial to ensuring patient survival. The five million coronary stents administered world-
wide each year remain present in the human artery for the lifetime of the patient. This has
resulted in the emergence of several serious side effects. A bioabsorbable metal stent that
harmlessly erodes away over time could minimize the normal chronic risks associated with
permanent stents.
Our laboratory has been working to refine the composition and microstructure of biodegradable
Zn-based binary alloys and test their behavior in the vascular environment over the last four
years in an effort to develop a metal with mechanical properties and biocompatibility required for
endovascular stent applications. Having contributed enormously to the scientific understanding
of Zn-based systems, we are now ready to develop more complex Zn-based alloys with 2-3
alloying elements that meet benchmark values for biodegradable stents, including: 1) have
superior corrosion fatigue resistance that eliminates early stage (6 to 9 months) fracturing of
biodegradable stents (common problem in Mg-based and Zn-based stents prototyped in the last
several years); 2) maintain in vivo corrosion rates close to the 0.02 mm/year value; 3) exhibit
>200 MPa yield strength, and >25-30% elongation to failure; and 4) demonstrate
biocompatibility in terms of short- and long-term inflammatory responses, re-endothelialization,
and suppressed intimal hyperplasia, similar or better than 316L stainless steel (industrial
standard for stent materials).
总结
心脏病是巨大的社会利益,由于其对健康的巨大影响,在工业化
国家,特别是在发达国家,肥胖率很高,典型的饮食是
不利于心血管健康。虽然侵入性手术是不可取的,
这对确保患者存活至关重要。全世界有五百万个冠状动脉支架-
在病人的一生中,每年都有大量的血液存在于人体动脉中。这
导致了一些严重的副作用一种生物可吸收金属支架,
随着时间的推移无害地侵蚀掉,可以最大限度地减少与
永久性支架。
我们的实验室一直致力于改进可生物降解的
锌基二元合金,并测试其在血管环境中的行为,在过去的四个
多年来一直致力于开发具有机械性能和生物相容性的金属,
血管内支架应用。对科学认识做出了巨大贡献
锌基系统,我们现在准备开发更复杂的锌基合金与2-3
符合生物可降解支架基准值的合金元素,包括:1)具有
上级耐腐蚀疲劳性,消除了早期(6至9个月)断裂,
生物可降解支架(上一个原型的镁基和锌基支架中的常见问题)
几年); 2)保持体内腐蚀速率接近0.02 mm/年值; 3)表现出
>200 MPa屈服强度,和>25-30%断裂伸长率;和4)证明
在短期和长期炎症反应,再内皮化,
和抑制内膜增生,类似于或优于316L不锈钢(工业
支架材料的标准)。
项目成果
期刊论文数量(0)
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Jaroslaw W Drelich其他文献
Jaroslaw W Drelich的其他文献
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{{ truncateString('Jaroslaw W Drelich', 18)}}的其他基金
Novel Bioresorbable Vascular Scaffolds with Uniform Biodegradation
具有均匀生物降解性的新型生物可吸收血管支架
- 批准号:
10930188 - 财政年份:2023
- 资助金额:
$ 36.97万 - 项目类别:
Corrosion Fatigue Resistant and Intimal Hyperplasia Suppressive Biometal for Bioabsorbable Stents
用于生物可吸收支架的抗腐蚀疲劳和内膜增生抑制生物金属
- 批准号:
10183308 - 财政年份:2019
- 资助金额:
$ 36.97万 - 项目类别:
Improved Biocompatibility and Biodegradation of Zn-based Stent Materials through Surface Nano-Engineering
通过表面纳米工程改善锌基支架材料的生物相容性和生物降解性
- 批准号:
8871928 - 财政年份:2015
- 资助金额:
$ 36.97万 - 项目类别:
Improved Biocompatibility and Biodegradation of Zn-based Stent Materials through Surface Nano-Engineering
通过表面纳米工程改善锌基支架材料的生物相容性和生物降解性
- 批准号:
9035393 - 财政年份:2015
- 资助金额:
$ 36.97万 - 项目类别:
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- 批准号:
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- 资助金额:
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Grant-in-Aid for Developmental Scientific Research (B).