Corrosion Fatigue Resistant and Intimal Hyperplasia Suppressive Biometal for Bioabsorbable Stents

总结 心脏病是巨大的社会利益，由于其对健康的巨大影响，在工业化 国家，特别是在发达国家，肥胖率很高，典型的饮食是 不利于心血管健康。虽然侵入性手术是不可取的， 这对确保患者存活至关重要。全世界有五百万个冠状动脉支架- 在病人的一生中，每年都有大量的血液存在于人体动脉中。这 导致了一些严重的副作用一种生物可吸收金属支架， 随着时间的推移无害地侵蚀掉，可以最大限度地减少与 永久性支架。 我们的实验室一直致力于改进可生物降解的 锌基二元合金，并测试其在血管环境中的行为，在过去的四个 多年来一直致力于开发具有机械性能和生物相容性的金属， 血管内支架应用。对科学认识做出了巨大贡献 锌基系统，我们现在准备开发更复杂的锌基合金与2-3 符合生物可降解支架基准值的合金元素，包括：1）具有 上级耐腐蚀疲劳性，消除了早期（6至9个月）断裂， 生物可降解支架（上一个原型的镁基和锌基支架中的常见问题） 几年）; 2）保持体内腐蚀速率接近0.02 mm/年值; 3）表现出 >200 MPa屈服强度，和>25-30%断裂伸长率;和4）证明 在短期和长期炎症反应，再内皮化， 和抑制内膜增生，类似于或优于316L不锈钢（工业 支架材料的标准）。

Summary Heart disease is of great societal interest due to its drastic impact on health in industrialized nations, especially in developed countries where obesity rates are high and the typical diet is not conducive to cardiovascular health. While invasive procedures are not desirable, they are often crucial to ensuring patient survival. The five million coronary stents administered world- wide each year remain present in the human artery for the lifetime of the patient. This has resulted in the emergence of several serious side effects. A bioabsorbable metal stent that harmlessly erodes away over time could minimize the normal chronic risks associated with permanent stents. Our laboratory has been working to refine the composition and microstructure of biodegradable Zn-based binary alloys and test their behavior in the vascular environment over the last four years in an effort to develop a metal with mechanical properties and biocompatibility required for endovascular stent applications. Having contributed enormously to the scientific understanding of Zn-based systems, we are now ready to develop more complex Zn-based alloys with 2-3 alloying elements that meet benchmark values for biodegradable stents, including: 1) have superior corrosion fatigue resistance that eliminates early stage (6 to 9 months) fracturing of biodegradable stents (common problem in Mg-based and Zn-based stents prototyped in the last several years); 2) maintain in vivo corrosion rates close to the 0.02 mm/year value; 3) exhibit >200 MPa yield strength, and >25-30% elongation to failure; and 4) demonstrate biocompatibility in terms of short- and long-term inflammatory responses, re-endothelialization, and suppressed intimal hyperplasia, similar or better than 316L stainless steel (industrial standard for stent materials).