Study on clinical application of thoracoscopic greater splanchnicectomy for the relief of intractable abdominal pain
胸腔镜下内脏大切除术缓解顽固性腹痛的临床应用研究
基本信息
- 批准号:09671248
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
[Introduction] To relieve intractable abdominal pain in the patients with unresectable pancreas cancer or chronic pancreatitis, we have clinically applied greater splanchnicectomy to such patients. Here, we discuss on the clinical significance of the procedure based on our experience.[Patients & Methods] During the period of 1994 though 1999, 27 patients (23 pancreas cancer and 4 chronic pacreatitis; 15 male and 12 female; age of 36-76 year-old) underwent either left only (n=17) or bilateral (10) greater splanchnicectomy; either transthoracic (16 thoracoscopy) or transhiatal (11 laparotomy) approach was chosen for the procedure. The effectiveness of the procedure was postoperatively evaluated on a 3-graded scale as complete disappearance, partial reduction, and no change, of the preexisting pain.[Results] Both transthoracic and transhiatal procedures were completed in all patients without major troubles. No detrimental effects other than a transient drop of the mean arterial pressure ( … More <45 mmHg) were observed after neurotomy. Overall, the preexisting upper abdominal pain completely disappeared immediately after splanchnicectomy in 20 (83%) out of 24 patients in whom we could assess the degree of abdominal pain. Pain in the right upper abdomen, however, did not disappear in 4 patients undergoing left splanchnicectomy alone. Among 19 pancreas cancer patients who had no abdominal pain immediately after splanchnicectomy, 6 patients developed lower abdominal and/or back pain at and after 1 week -3 months post-splanchnicectomy, though left upper abdominal pain never recurred in any patients. No pain recurred in the patients with chronic pancreatitis.[Discussion & Conclusion] Results of the present study suggest that rater splanchnicectomy is a safe and efficacious procedure for the relief of intractable abdominal pain associated with pancreas diseases. Transhiatal approach seems to be suitable for the patients who undergo laparotomy for biliary tract diversion and/or gastrointestinal anastomosis, while transthoracic splanchnicectomy may be applied to those requiring no such procedures. Less
[引言]为了缓解不能切除的胰腺癌或慢性胰腺炎患者的顽固性腹痛,我们在临床上对这类患者进行了更大的内脏切除术。本文结合临床经验,对该手术的临床意义进行讨论。[病例与方法] 1994 ~ 1999年共收治胰腺癌23例,慢性胰腺炎4例,男15例,女12例,年龄36-76岁,行左侧内脏大神经切除术17例,双侧内脏大神经切除术10例,经胸(胸腔镜)16例,经裂孔(开腹)11例。术后根据3级量表评价手术的有效性,即既存疼痛完全消失、部分减轻和无变化。[结果]所有患者均顺利完成经胸、经裂孔手术,无严重并发症。除平均动脉压短暂下降外,无其他有害影响( ...更多信息 <45 mmHg)。总体而言,在我们可以评估腹痛程度的24名患者中,有20名(83%)在内脏切除术后立即完全消失。然而,仅行左侧内脏神经切除术的4例患者右上腹疼痛并未消失。19例胰腺癌患者术后即刻无腹痛,6例患者术后1周~ 3个月出现下腹痛和(或)背痛,但左上腹痛无复发。慢性胰腺炎患者无疼痛复发。[讨论与结论]内脏大神经切除术是一种安全、有效的治疗胰腺疾病所致顽固性腹痛的方法。经裂孔入路适用于开腹胆道改道和(或)胃肠道吻合的患者,而经胸内脏大神经切除术适用于不需要此类手术的患者。少
项目成果
期刊论文数量(32)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
高橋毅: "進行性膵癌における腹部頑痛に対する経食道裂孔性大内臓神経切離術"日本消化器外科学会雑誌. 31(6). 1361 (1998)
Takeshi Takahashi:“经食管裂孔内脏大神经横断术治疗晚期胰腺癌腹部强直”,日本胃肠外科杂志 31(6)。
- DOI:
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- 影响因子:0
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Tsuyoshi Takahashi: "Transhiatal greater splanchnicectomy for the treatment of intractable abdominal pain"Shujutsu (Operation). 52(11). 1911-1914 (1998)
高桥刚:“经裂孔大内脏切除术治疗顽固性腹痛”Shujutsu(手术)。
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- 影响因子:0
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高橋 毅、他: "末期膵癌の腹痛に対する胸腔鏡下左大内臓神経切離術の臨床的意義" 日本外科学会雑誌. 97(2). 221- (1997)
Takeshi Takahashi 等:“胸腔镜下左内脏大神经切断治疗终末期胰腺癌腹痛的临床意义”,日本外科学会杂志 97(2)。
- DOI:
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- 期刊:
- 影响因子:0
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Tsuyoshi Takahashi: "Clinical assessment of transhiatal greater splanchnicectomy in pancreas cancer patients with intractable abdominal pain."Japanese Journal of Gastoenterology. 96(suppl). A249 (1999)
Tsuyoshi Takahashi:“对患有顽固性腹痛的胰腺癌患者进行经裂孔大内脏切除术的临床评估。”日本胃肠病学杂志。
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- 发表时间:
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- 影响因子:0
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Ken Shimada: "Transhiatal greater splanchnicectomy for intractable abdominal pain in the patients with advanced pancreas cancer."Journsl ofJapan Surgical Association. 100(suppl). 304 (1999)
Ken Shimada:“经裂孔大内脏切除术治疗晚期胰腺癌患者的顽固性腹痛。”日本外科协会杂志。
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- 影响因子:0
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TAKAHASHI Tsuyoshi其他文献
TAKAHASHI Tsuyoshi的其他文献
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{{ truncateString('TAKAHASHI Tsuyoshi', 18)}}的其他基金
Construction of Detection System for Ligand Screening in Solution Using Peptide Generation based on Molecular Interactions
基于分子相互作用的肽生成技术构建溶液中配体筛选检测系统
- 批准号:
24651237 - 财政年份:2012
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of evaluation method for a joining part by friction welding which subjected to thermo-mechanical cyclic loading under sever environment
严酷环境下承受热机械循环载荷的摩擦焊接连接件评价方法的开发
- 批准号:
22560093 - 财政年份:2010
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Control of amyloidogenic proteins using surface-engineered β-barrel proteins
使用表面工程β-桶蛋白控制淀粉样蛋白
- 批准号:
21710225 - 财政年份:2009
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Construction of fluorescent proteins having amyloid b-peptide (Ab) sequence and FRET detection of Ab aggregates
具有淀粉样 b 肽 (Ab) 序列的荧光蛋白的构建和 Ab 聚集体的 FRET 检测
- 批准号:
19710183 - 财政年份:2007
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Immunotherapy with human natural killer T cells
使用人类自然杀伤 T 细胞进行免疫治疗
- 批准号:
19599004 - 财政年份:2007
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Water purification in rural area using self-purification function
利用自净功能净化农村水
- 批准号:
09460108 - 财政年份:1997
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Rural Development Planning for Environmental Conservation
农村环境保护发展规划
- 批准号:
06452366 - 财政年份:1994
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Studies on the establishment of transformed apple-rootstock plants resistant to virus diseases by means of recombinant DNA technology
利用重组DNA技术建立抗病毒病苹果砧木转化植株的研究
- 批准号:
04556006 - 财政年份:1992
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Studies on the Rational Operation of Rural Wastewater Treatment Plant
农村污水处理厂合理运行研究
- 批准号:
02454085 - 财政年份:1990
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Field Study on Dephosphorization for Rural Sewage Treatment
农村污水处理除磷现场研究
- 批准号:
62460205 - 财政年份:1987
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)