Control of amyloidogenic proteins using surface-engineered β-barrel proteins

先前的研究表明，在其表面呈现伪淀粉样结构的工程β-桶蛋白可以与阿尔茨海默病淀粉样蛋白β-肽（Aβ）紧密结合。在本研究中，利用工程β桶蛋白对Aβ的毒性进行了抑制。此外，利用β-桶蛋白的设计策略扩展到与亨廷顿氏病相关的聚谷氨酰胺蛋白。

The previous study demonstrated that the engineered β-barrel proteins presenting pseudo-amyloid structures on their surfaces can bind tightly to Alzheimer's amyloid β-peptide (Aβ). In this study, suppression of Aβ toxicity using the engineered β-barrel proteins was evaluated. Moreover, the design strategy using β-barrel proteins was expanded for polyglutamine proteins that relate Huntington's disease.