Mechanism of prevention of lung metastasis or sarcoma by tumor-associated macrophage
肿瘤相关巨噬细胞预防肺转移或肉瘤的机制
基本信息
- 批准号:09671467
- 负责人:
- 金额:$ 0.7万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1998
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Antitumor effect of the intra-tumoral injection of Cepharanthin<encircledR> and staphylococcal enterotoxin B was evaluated using F 344 male rats bearing transplantable rat-osteosarcoma, S-SLM.A macroscopic lung metastatic nodule of the tumor was transplanted into subcutaneous back space, and 0.5 mg Cepharanthin and 2 pg staphylococcal enterotoxin B were injected into the tumor on day 12, 13 and 14. On day 28, all animals were euthanized in overdose of pentobarbital sodium, and the transplanted tumor and lung were examined. The wet weight of the lung of the rats treated with Gepharanthin and staphylococcal enterotoxin B was significantly lower, and the number of apoptosis of the lung metastatic nodules was significantly higher than those of the control and treated with only Cepharanthin or staphylococcal enterotoxin B.In the transplanted tumors, an infiltration of TRAP (tartrate-resistant acid phosphatase)-positive multinucleated giant cells was prominent in the rats treated with Cepharanthin and staphylococcus enterotoxin B.These findings indicate that intra-tumoral injection of Cepharanthin and staphylococcal enterotoxin B induced infiltration of TRAP-positive multinucleated giant cells within the transplanted rat-osteosarcoma, and prevent their lung metastasis.
在F344雄性可移植大鼠骨肉瘤S-SLM模型上,观察头孢菌素和葡萄球菌肠毒素B瘤内注射的抗肿瘤作用。在第12、13和14天,将肉眼可见的肺转移结节移植到皮下,分别注射头孢菌素0.5 mg和葡萄球菌肠毒素B 2pg。第28天,大剂量戊巴比妥钠对所有动物实施安乐死,并检查移植瘤和肺组织。头孢菌素和葡萄球菌肠毒素B组大鼠肺湿重显著低于对照组,肺转移瘤结节细胞凋亡率显著高于单纯头孢菌素和葡萄球菌肠毒素B组,移植瘤中TRAP阳性多核巨细胞在头孢菌素和金黄色葡萄球菌肠毒素B治疗组大鼠肺组织中有明显的渗出,提示头孢菌素和葡萄球菌肠毒素B瘤内注射可诱导TRAP阳性多核巨细胞在移植瘤内的浸润,从而阻止其肺转移。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K.okada et al.: "Membranocystic lesion in the cartilaginous tissue." Pathology International. 48. 384-388 (1998)
K.okada 等人:“软骨组织中的膜囊性病变。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
K.Okada, et al.: "Cartilaginous membranocystic lesions mimicking membranous lipodystrophy of bone." Patholoqy International. 48. 384-388 (1998)
K.Okada 等人:“模拟骨膜性脂肪营养不良的软骨膜囊性病变。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
S.Yamada, K.Okada, et al.: "Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A55 kDa b-regulatory subunit isotypes." Jpn J Cancer Res. 89. 1014-1019 (1998)
S.Yamada、K.Okada 等人:“大鼠蛋白磷酸酶 2A55 kDa b 调节亚基同种型的 Bra、Brb 和 Brg 基因的连锁图谱。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
K.Okada, et al.: "High-grade surface osteosarcoma." Cancer. in press.
K.Okada 等人:“高级表面骨肉瘤”。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
S.Yamada, K.Okada, et al.: "Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A55 kDa b-requlatory subunitisotypes." Jpn J cancer Res. 89. 1014-1019 (1998)
S.Yamada、K.Okada 等人:“大鼠蛋白磷酸酶 2A55 kDa b 调节亚单位同种型的 Bra、Brb 和 Brg 基因的连锁图谱”。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
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OKADA Kyoji其他文献
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{{ truncateString('OKADA Kyoji', 18)}}的其他基金
Exercise induced expressions of transforming factors in skeletal muscle, fat tissue, vessel walls, and hippocampus.
运动诱导骨骼肌、脂肪组织、血管壁和海马体中转化因子的表达。
- 批准号:
23500834 - 财政年份:2011
- 资助金额:
$ 0.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Antitumor effect of acridine orange under ultrasonic irradiation in vitro
超声辐照下吖啶橙的体外抗肿瘤作用
- 批准号:
18591621 - 财政年份:2006
- 资助金额:
$ 0.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Ultrasound therapy for soft tissue sarcoma with new quinolone antibiotics as a sonodynamic compound
使用新型喹诺酮抗生素作为声动力化合物对软组织肉瘤进行超声治疗
- 批准号:
16591469 - 财政年份:2004
- 资助金额:
$ 0.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Enhanced antitumor effect of ultrasound in the presence of piroxicam in a mouse airpouch model.
在小鼠气袋模型中,在吡罗昔康存在下,超声波增强了抗肿瘤作用。
- 批准号:
11671414 - 财政年份:1999
- 资助金额:
$ 0.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An novel hematoporphyrin-anticancer drug conjugate for a therapy of lung metastasis of sarcoma.
一种新型血卟啉-抗癌药物缀合物,用于治疗肉瘤肺转移。
- 批准号:
07671566 - 财政年份:1995
- 资助金额:
$ 0.7万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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