Enhanced antitumor effect of ultrasound in the presence of piroxicam in a mouse airpouch model.

点击翻译按钮获取中文摘要

The antitumor effects of piroxicam, a non-steroidal anti-inflammatory drug, under ultrasonic irradiation on sarcoma 180 cells were examined in a mouse air pouch model. When piroxicam was added to sarcoma 180 suspension under the ultrasound irradiation (2 MHz, 10 W, 120 s), the mortality rate of tumor cells immediately after the irradiation and the survival rate of mice were significantly higher than those when ultrasound alone was applied, and these effects of piroxicam were dose-dependent. When Lhistidine was used with piroxicam, the mortality rate of the tumors cells after the irradiation was comparable with that when ultrasound alone was applied, and when D-mannitol was used concurrently, the antitumor effect was significantly greater than that when ultrasound alone was applied. Histological examinations of the air pouch including the surrounding tissue showed highly degenerative tumor tissue in the air pouch and normal appearance of surrounding tissue. The findings suggest that piroxicam enhances the antitumor effects of ultrasound in vivo by increasing the production of singlet oxygen without any damage to tissue surrounding the tumor.