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Electrical Stimulation for Preventing Disuse Changes of Musculoskeletal System ; Role of Various Physical Modalities.

电刺激预防肌肉骨骼系统废用性变化；

基本信息

批准号：
09671473
负责人：
AKAI Masami
金额：
$ 2.05万
依托单位：
THE UNIVERSITY OF TOKYO
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Physical inactivity causes a reduction m functional ability ("disuse changes") of musculoskeletal system. If there is a supplement to substitute decreased mechanical stress with other biophysical modalities, it could be a great help for the patient under bed rest or immobilization to prevent disuse changes. Under this hypothesis we have performed a series of experiments in order to find wether stimulation of physical modality (i.e. electricity or low-1evel laser) could decrease the amount of joint contracture made by immobilization in animal model or not. Recent success of electrical enhancement for bone healing expands its application to other tissues than bone, and to other aspects than repair process.Immobilization-induced changes of bone and cartilage as well as soft tissues in the dissected knee joint were assessed and compared between the groups. The specimen were examined mainly using biomechanical analysis for viscoelastic properties. Other examinations with bone densitometry or histomorphometry were also used. The results were promising with several statistically significant differences between the experiment specimen and the controls. However the tissue responses to these stimulation varied widely and it was hard to identify an optimal condition for each target tissue, Further accumulation of data on tissue responses caused by immobilization and by physical modalities will be needed.Apart from these animal experiments, a meta-analysis on electrical stimulation in controlled clinical trials was also performed to find supportive clinical evidence.

缺乏体力活动会导致肌肉骨骼系统的功能能力下降（“废用性变化”）。如果有一个补充，以取代减少机械应力与其他生物物理方式，这可能是一个很大的帮助下，病人卧床休息或固定，以防止废用性变化。在这一假设下，我们进行了一系列的实验，以确定物理形式的刺激（即电或低强度激光）是否可以减少动物模型制动引起的关节挛缩。近年来，电促进骨愈合的成功将其应用扩展到骨以外的其他组织，以及修复过程以外的其他方面。主要采用生物力学分析方法对标本进行粘弹特性检测。还使用了骨密度测定或组织形态测定等其他检查。结果是有希望的，实验标本和对照之间有几个统计学显著差异。然而，组织对这些刺激的反应差异很大，很难确定每个靶组织的最佳条件，需要进一步积累固定和物理方式引起的组织反应数据。除了这些动物实验，还进行了对照临床试验中的荟萃分析，以寻找支持性临床证据。