EFFECTS OF NMDA-ATAGONISTS AND ALPHA2-ADRENERGIC AGONISTS ON SPINAL AND CEREBRAL MICROCIRCULATION -ASSESSED WITH CLOSED SPINAL AND CRANIAL WINDOW TECHNIQUE-.

NMDA 激动剂和 α2 肾上腺素能激动剂对脊髓和大脑微循环的影响 - 使用闭合脊柱和颅窗技术进行评估 -。

• 批准号: 09671555
• 负责人: IIDA Hiroki
• 金额: $ 1.47万
• 依托单位: GIFU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671555/
• 关键词: NMDA antagonist; Alpha2-adrenergic agonist; Cerebral vessel; Spinal vessel; Microcirculation; α_2作動薬; 脳・脊髄循環; 微小循環

Pentobaribital anesthetized animals were prepared for measurement of cerebral and spinal pial vessel diameter in a cranial and a spinal window preparation. We investigated the experiments according to following protocols.(1) To investigate the effect of systemic pretreatment with dexmedetomidine on cerebrovascular response to isoflurane and sevoflurane.; The vasodilation of cerebral pial vessels induced by isoflurane and sevoflurane could be attenuated by the systemic administration of dexmedetomidine, and this interaction between dexmedetomidine and volatile anesthetics showed no evidence of dose dependency.(2) To investigate the effect of ketamine on cerebrovascular response to isoflurane and sevoflurane.; Ketamine itself did not induce cerebrovascular dilation. The vasodilation of cerebral pial vessels induced by isoflurane and sevoflurane could be attenuated by the systemic administration of ketamine, and the response of pial vessels to PaCO2 also attenuated.(3) To investigate the effects of alpha1- and alpha2-adrenergic agonists on spinal and cerebral pial vessels: Dexmedetomidine and clonidine constricted spinal vessels in a concentration-dependent manner, but such vasoconstrictions were smaller than those induced by phenylephrine and epinephrine. In cerebral vessels, greater constriction was induced by dexmedetomidine and clonidine than those induced by phenylephrine and epinephrine.(4) To investigate the effects of spinal alpha2-adrenergic agonists on cerebrovascular reactivity to hypercapnia and hypoxia.: The presence of alpha2-adrenergic agonist administered intrathecally into the lumbar spinal region attenuated hypercapnic, but not hypoxic cerebral vasodilation, probably via a stimulation of central alpha2-adrenergic receptors of the central nervous system.

制备戊巴比妥麻醉动物，用于测量颅骨和脊髓窗制备中的脑和脊髓软脑膜血管直径。我们根据以下方案研究实验。(1)目的探讨右美托咪定全身预处理对异氟醚和七氟醚诱导脑血管反应的影响。右美托咪定全身给药可减弱异氟烷和七氟烷诱导的脑软膜血管舒张，并且右美托咪定与挥发性麻醉剂之间的相互作用未显示剂量依赖性证据。(2)目的探讨氯胺酮对异氟醚和七氟醚所致脑血管反应的影响。氯胺酮本身不会引起脑血管扩张。氯胺酮可减弱异氟醚和七氟醚对软脑膜血管的舒张作用，并降低软脑膜血管对PaCO 2的反应性。(3)研究α 1-和α 2-肾上腺素能激动剂对脊髓和大脑软脑膜血管的影响：右美托咪定和可乐定以浓度依赖性方式收缩脊髓血管，但这种血管收缩作用小于苯肾上腺素和肾上腺素诱导的血管收缩作用。在脑血管中，右美托咪定和可乐定引起的收缩比苯肾上腺素和肾上腺素引起的收缩大。(4)研究脊髓α 2-肾上腺素能受体激动剂对高碳酸血症和缺氧的脑血管反应性的影响。腰椎区域鞘内注射α 2-肾上腺素能激动剂可减弱高碳酸血症，但不减弱缺氧性脑血管舒张，可能是通过刺激中枢神经系统的中枢α 2-肾上腺素能受体。

项目成果

Hiroto Ohata, et al.: "Hemodynamic responses induced by dopamine and dobutamine in anesthetized patients premedicated with clonidine"Anesth Analg. 89. 843-848 (1999)

Hiroto Ohata 等人：“麻醉患者术前服用可乐定时多巴胺和多巴酚丁胺诱导的血流动力学反应”Anesth Analg。

Ohata H, Iida H, Dohi S, Watanabe Y: "Intravenous dexmedetomidine inhibits cerebrocascular dilation induced by isoflurane and sevoflurane."Anesth Analg. 89. 370-377 (1999)

Ohata H、Iida H、Dohi S、Watanabe Y：“静脉注射右美托咪定可抑制异氟烷和七氟烷诱导的脑血管扩张。”Anesth Analg。

Hiroki Iida, et al.: "Attenuated additional hypocapnic constriction, but not hypercopnic dilation of spinal pial arterioles during spinal ropivacuine"Anesth Analg. 89. 1510-1513 (1999)

Hiroki Iida 等人：“脊髓罗哌奎宁期间，减弱了额外的低碳酸血症收缩，但并未减弱脊髓软膜小动脉的高碳酸血症扩张”Anesth Analg。

Iida H, Ohata H, Iida M, Watanabe Y, Dohi S: "Isoflurane and sevoflurane induce vasodilation of cerebral vessels viaATP-sensitive KィイD1+ィエD1 channel activation."Anesthesiology. 89. 954-960 (1998)

Iida H、Ohata H、Iida M、Watanabe Y、Dohi S：“异氟烷和七氟烷通过 ATP 敏感的 KD1+D1 通道激活诱导脑血管舒张。”麻醉学 89. 954-960 (1998)。

Mami Iida,et al.: "Mechanisms underlying cerebrovascuar effects of cigreHe smoking in rats in vivo" Stroke. 29. 1656-1665 (1998)

Mami Iida 等人：“吸烟对大鼠体内的脑血管影响的机制”中风。