Analysis of intracellular mechanisms and related factors regarding spinal protection by remote preoonditioning
远程预适应脊柱保护的细胞内机制及相关因素分析
基本信息
- 批准号:18591697
- 负责人:
- 金额:$ 2.27万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2006
- 资助国家:日本
- 起止时间:2006 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Pentobarbital anesthetized rabbits were prepared for measurement of cerebral pial vessel diameter in a cranial window preparation or spinal cord partial tissue oxygen pressure (PtO2). We investigated the experiments according to following protocols.1) We studied the effect of aortic clamping and declamping as a remote preconditioning intervention on cerebral pial vessel diameter. Although infrarenal aortic cross-clamping did not affect pial vessel diameter, release of a 20-min aortic cross-clamp caused pial arterioles to dilate and then constrict. A significant constriction persisted for at least 60 min. To clarify the mechanism of remote preconditioning regarding humoral factor, we examined whether angiotensin II typel receptor blocker, Rho-kinase inhibitor, or free radical scavenger, would affect the respose observed after aortic cross-clamping and release on cerebral vessels. All three drugs significantly attenuated the constriction of pial arterioles. Thus angiotensin II, Rho-kinase, and free radical could be possible to be candidates for humoral factors related to remote conditioning on spinal protection.2) We measured directly the tissue oxygen partial pressure of the spinal cord to assess the efficacy of remote preconditioning in preventing apinal cord ischemic injury in an experimental model. PtO2 were significantly lower in the preconditioning intervention group at 20 min after aortic cross-clamping and 0, 2 min after aortic unclamping. Remote preconditioning performed in fore and hind legs protected the decrease of PtO2 compared with control group. Thus, the effect on PtO2 by such intervention may relate to the mechanism of spinal protection induced by remote preconditioning by transient upper and lower limbs ischemia.
以戊巴比妥钠麻醉兔为实验对象,在颅窗或脊髓局部组织氧分压(PtO2)的基础上测量软脑膜血管内径。我们根据以下方案进行实验研究:1)我们研究了作为远程预适应干预的主动脉阻断和去阻断对脑软膜血管内径的影响。尽管肾下主动脉阻断对软膜血管直径没有影响,但释放20分钟的主动脉阻断会导致软膜小动脉扩张,然后收缩。明显的收缩持续了至少60分钟。为了阐明体液因子的远程预适应机制,我们研究了血管紧张素II受体阻滞剂、Rho-Kinase抑制剂或自由基清除剂是否会影响主动脉阻断和脑血管释放后的反应。这三种药物都显著减轻了软脑膜小动脉的收缩。因此,血管紧张素II、Rho-激酶和自由基可能成为远程脊髓保护相关体液因子的候选者。2)在实验模型中,我们直接测量脊髓组织氧分压,以评估远程预适应预防脊髓缺血损伤的效果。预适应干预组在主动脉阻断后20min和开放后0min、2min时PtO2显著降低。与对照组相比,在前后肢进行远程预适应可保护PtO2的降低。因此,这种干预对PtO2的影响可能与短暂性上、下肢缺血远程预适应诱导脊髓保护的机制有关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
「麻酔科医はどこまで臓器保護に関与できるか?」「脊髄保護に関して」
“麻醉师可以在多大程度上参与器官保护?”
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:上林卓彦;住谷昌彦;宮内哲;柴田政彦;眞下節;飯田宏樹
- 通讯作者:飯田宏樹
Rho-kinase inhibitor attenuated pial arteriolar constriction after unclamping of aortic cross-clamp.
Rho激酶抑制剂可减弱主动脉夹钳松开后软脑膜小动脉的收缩。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Kaku;R.;Yokoyama;M.;et. al.;Motoyasu Takenaka
- 通讯作者:Motoyasu Takenaka
Opioid Receptor Independent Effects of Oxycodone on TTX-RNa^+Currents in Rat Sensory Neurons.
羟考酮对大鼠感觉神经元 TTX-RNA^ 电流的阿片受体独立影响。
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:松崎孝;横山正尚;他;Yoko Osawa
- 通讯作者:Yoko Osawa
The comparative effects of intravenous nicardipine and prostaglandin E1 on the cerebral pial arteriolar constriction seen after unclamping of an aortic cross-clamp in rabbits
- DOI:10.1213/01.ane.0000253493.76249.54
- 发表时间:2007-03-01
- 期刊:
- 影响因子:5.7
- 作者:Kumazawa, Masahiko;Iida, Hiroki;Dohi, Shuji
- 通讯作者:Dohi, Shuji
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IIDA Hiroki其他文献
IIDA Hiroki的其他文献
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{{ truncateString('IIDA Hiroki', 18)}}的其他基金
Development of Asymmetric Polymer Catalysts Based on Controlled Helical Structure
基于可控螺旋结构的不对称聚合物催化剂的研制
- 批准号:
23750123 - 财政年份:2011
- 资助金额:
$ 2.27万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
The roles of sex hormone and gender difference for spinal cord protection in spinal cord ischemia
性激素及性别差异在脊髓缺血中的脊髓保护作用
- 批准号:
21591970 - 财政年份:2009
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$ 2.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CHANGES IN CEREBROSPINAL MLCROC1RCULATION DURING AND AFTER ABDOMINAL AORTIC CROSS-CLAMPIN : AN UNDERLYING MECHANISM
腹主动脉交叉钳夹期间和之后脑脊髓 MLCR 的变化:潜在机制
- 批准号:
13671570 - 财政年份:2001
- 资助金额:
$ 2.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
EFFECTS OF ALPHA2-ADRENERGIC AGONISTS AND NMDA-ANTAGONISTS ON CEREBRAL MICROCIRCULATION UNDER THE HYPOTHERMIC CONDITION -ASSESSED WITH CLOSED CRANIAL WINDOW TECHNIQUE-.
α2-肾上腺素能激动剂和 NMDA 拮抗剂对低温条件下脑微循环的影响 - 用闭颅窗技术评估 -。
- 批准号:
11671489 - 财政年份:1999
- 资助金额:
$ 2.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
EFFECTS OF NMDA-ATAGONISTS AND ALPHA2-ADRENERGIC AGONISTS ON SPINAL AND CEREBRAL MICROCIRCULATION -ASSESSED WITH CLOSED SPINAL AND CRANIAL WINDOW TECHNIQUE-.
NMDA 激动剂和 α2 肾上腺素能激动剂对脊髓和大脑微循环的影响 - 使用闭合脊柱和颅窗技术进行评估 -。
- 批准号:
09671555 - 财政年份:1997
- 资助金额:
$ 2.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studies on the effects of alpha-agonist and Ca antagonist for maintaining cerebral blood flow after cardiopulmonary resuscitation.
α受体激动剂和Ca拮抗剂对心肺复苏后脑血流维持作用的研究
- 批准号:
06671513 - 财政年份:1994
- 资助金额:
$ 2.27万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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