EFFECTS OF ALPHA2-ADRENERGIC AGONISTS AND NMDA-ANTAGONISTS ON CEREBRAL MICROCIRCULATION UNDER THE HYPOTHERMIC CONDITION -ASSESSED WITH CLOSED CRANIAL WINDOW TECHNIQUE-.

α2-肾上腺素能激动剂和 NMDA 拮抗剂对低温条件下脑微循环的影响 - 用闭颅窗技术评估 -。

• 批准号: 11671489
• 负责人: IIDA Hiroki
• 金额: $ 1.66万
• 依托单位: GIFU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671489/
• 关键词: Alpha2-adrenergic agonist; NMDA antagonist; Cerebral vessel; Microcirculation; Hypothermia

Pentobarbital anesthetized animals were prepared for measurement of cerebral pial vessel diameter in a cranial window preparation. We investigated the experiments according to following protocols.(1) To investigate the effect of ketamine on cerebrovascular response to isoflurane and sevoflurane. ; Ketamine itself did not induce cerebrovascular dilation. The vasodilation of cerebral pial vessels induced by isoflurane and sevoflurane could be attenuated by the systemic administration of ketamine, and the response of pial vessels to PaCO2 also attenuated.(2) To compare the effect of topical dexmedetomidine on cerebral pial vessel diameter under normothermic or hypothemic condition ; In normothermic condition the topical administration of 10^<-7> M and 10^<-5> M dexmedetomidine induced a vasodilation of cerebral pial vessels, whereas in hypothermic condition the topical administration of the same concentration of dexmedetomidine induced a vasoconstriction of cerebral pial vessels. The higher concentration (10^<-3>M) of dexmedetomidine induced a vasodilation of cerebral pial vessels in both normothermic and hypothermic condition.

用戊巴比妥麻醉动物，在颅窗制备中测量脑脑血管直径。我们根据以下方案调查实验。(1)探讨氯胺酮对异氟醚和七氟醚的脑血管反应的影响。;氯胺酮本身不引起脑血管扩张。异氟醚和七氟醚所致的脑脊膜血管舒张可通过全身给药氯胺酮减弱，脑脊膜血管对PaCO2的反应也可减弱。(2)比较常温和低温条件下外用右美托咪定对脑血管直径的影响；在常温条件下，局部给予10^<-7> M和10^<-5> M右美托咪定可引起脑血管舒张，而在低温条件下，局部给予相同浓度的右美托咪定可引起脑血管收缩。在常温和低温条件下，右美托咪定的较高浓度（10^<-3>M）均可引起脑血管舒张。

项目成果

Iida H, Ohata H, Iida M, Watanabe Y, Nagase K, Dohi S.: "Attenuated additional hypocapnic constriction, but not hypercapnic dilation, of spinal pial arterioles during spinal ropivacaine."Anesth Analg. 89. 1510-1513 (1999)

Iida H、Ohata H、Iida M、Watanabe Y、Nagase K、Dohi S.：“脊髓罗哌卡因期间脊髓软膜小动脉的额外低碳酸血症收缩，但不是高碳酸血症扩张。”麻醉模拟。

Iida H et al.: "Attenuated additional hypocapnic constriction, but not hypercapnic dilation, of spinal pial arterioles during spinal ropivacaine."Anesth Analg. 89. 1510-3 (1999)

Iida H 等人：“脊髓罗哌卡因期间脊髓软膜小动脉的额外低碳酸血症收缩，但没有高碳酸血症扩张。”Anesth Analg。

Takenaka M et al.: "Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodi lation in a anesthetized rabbits."Anesthesiology. 92. 1376-84 (2000)

Takenaka M 等人：“鞘内注射右美托咪定可减弱麻醉兔子的高碳酸血症，但不会减弱缺氧性脑血管舒张。”麻醉学。

Ohata H, Iida H, Nagase K, Dohi S: "Effects of topical and intravenous ketamine on cerebral microcirculation in dogs under pentobarbital or isoflurane anesthesia."Anesth Analg. (Submitted).

Ohata H、Iida H、Nagase K、Dohi S：“局部和静脉注射氯胺酮对戊巴比妥或异氟烷麻醉下狗脑微循环的影响。”麻醉分析。

Takenaka M et al.: "Intrathecal Dexmedetomidine Attenuates Hypercapnic but Not Hypoxic Cerebral Vasodilation in Anesthetized Rabbits."Anesthesiology. 92. 1376-84 (2000)

Takenaka M 等人：“鞘内注射右美托咪定可减弱麻醉兔的高碳酸血症，但不会减弱缺氧性脑血管舒张。”麻醉学。