Effects of Nitric Oxide Synthase Inhibitor on Organ Blood Flow Distribution during Hemorrhagic Shock

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1, We investigated the effects of nitric oxide synthase (NOS) inhibitor on organ blood flow distribution in hemorrhagic shock. In anesthetized dogs, hypotension (mean arterial pressure=4OmmHg) was achieved by draining blood from their circulation into a reservoir and maintained for 90 mm by further removing or transfusing blood. Following the 90 mm shock period, 10mg/kg N-nitro-L-arginine methyl ester (L-NAME group : n=8) or saline (control group : n=8) was administered. Organ blood flow distribution was measured before hypotension and I 5mm after L-NAME or saline administration in both groups by the radioactive microsphere method. There was no signicant difference in organ blood flow distribution between the two groups. A physiological shift in blood flow distribution during hemorrhagic shock to the brain and heart (centralization) was observed in both groups. (Circulation Control 1 8 ; 541-547 : 1997)2, We also investigated the change of plasma concentration of adrenomedullin, a novel vasodilating peptide, in hemorrhgic shock. In anesthetized dogs, hypotension (mean arterial pressure=4OmmHg) was achieved by draining blood from their circulation into a reservoir and maintained for 90 mm by further removing or transfusing blood. Plasma concentration of adrenomedullin was increased in hemorrhagic dogs (n=8) more significantly than in sham dogs (n=8). (Anesthesia & Analgesia 88 ; 326-328 : 1999)