Effects of Nitric Oxide Synthase Inhibitor on Organ Blood Flow Distribution during Hemorrhagic Shock

一氧化氮合酶抑制剂对失血性休克器官血流分布的影响

基本信息

  • 批准号:
    09671586
  • 负责人:
  • 金额:
    $ 1.86万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1998
  • 项目状态:
    已结题

项目摘要

1, We investigated the effects of nitric oxide synthase (NOS) inhibitor on organ blood flow distribution in hemorrhagic shock. In anesthetized dogs, hypotension (mean arterial pressure=4OmmHg) was achieved by draining blood from their circulation into a reservoir and maintained for 90 mm by further removing or transfusing blood. Following the 90 mm shock period, 10mg/kg N-nitro-L-arginine methyl ester (L-NAME group : n=8) or saline (control group : n=8) was administered. Organ blood flow distribution was measured before hypotension and I 5mm after L-NAME or saline administration in both groups by the radioactive microsphere method. There was no signicant difference in organ blood flow distribution between the two groups. A physiological shift in blood flow distribution during hemorrhagic shock to the brain and heart (centralization) was observed in both groups. (Circulation Control 1 8 ; 541-547 : 1997)2, We also investigated the change of plasma concentration of adrenomedullin, a novel vasodilating peptide, in hemorrhgic shock. In anesthetized dogs, hypotension (mean arterial pressure=4OmmHg) was achieved by draining blood from their circulation into a reservoir and maintained for 90 mm by further removing or transfusing blood. Plasma concentration of adrenomedullin was increased in hemorrhagic dogs (n=8) more significantly than in sham dogs (n=8). (Anesthesia & Analgesia 88 ; 326-328 : 1999)
1、我们研究了一氧化氮合酶(NOS)抑制剂对失血性休克器官血流分布的影响。在麻醉狗中,通过将血液从其循环中排入储库并通过进一步去除或输血维持90mm来实现低血压(平均动脉压=40mmHg)。 90毫米休克期后,给予10mg/kg N-硝基-L-精氨酸甲酯(L-NAME组:n=8)或盐水(对照组:n=8)。采用放射性微球法测量两组患者低血压前及L-NAME或生理盐水给药后5mm时器官血流分布。两组器官血流分布无显着差异。在失血性休克期间,两组患者均观察到大脑和心脏的血流分布发生了生理性变化(集中化)。 (Circulation Control 1 8 ; 541-547 : 1997)2,我们还研究了失血性休克中肾上腺髓质素(一种新型血管舒张肽)血浆浓度的变化。在麻醉狗中,通过将血液从其循环中排入储库并通过进一步去除或输血维持90mm来实现低血压(平均动脉压=40mmHg)。出血狗(n = 8)中肾上腺髓质素的血浆浓度比假手术狗(n = 8)更显着增加。 (麻醉与镇痛 88;326-328:1999)

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
藤岡 丞: "出血性ショックにおける一酸化窒素合成酵素阻害剤の投与が臓器血流分布に及ぼす影響" 循環制御. 18. 541-547 (1997)
Jo Fujioka:“一氧化氮合酶抑制剂对失血性休克器官血流分布的影响”《循环控制》18. 541-547 (1997)。
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Susumu Fujioka: "Plasma concentration of actenamedllinis increased in hemarrhagic shock in dogs" Anesthesia & Analgesia. 88. 326-328 (1999)
Susumu Fujioka:“狗失血性休克时血浆中的 Actenamedllinis 浓度升高”
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Susumu Fujioka: "Plasma concentration of act enomedulin is increased in hemarrhagic shock in dogs" Anesthesia&Analgesia. 88. 326-328 (1999)
Susumu Fujioka:“犬失血性休克时 Act enomedulin 的血浆浓度升高”
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"Effects of nitric oxide synthase inhibitor on organ flow distribution during hemorrhagic shock" Circulation Control. 18. 541-547 (1997)
“一氧化氮合酶抑制剂对失血性休克期间器官流量分布的影响”循环控制。
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"Plasma concentration of adrenomedullin is increased in hemorrhagic shock in dogs" Anesthesia & Analgesia. 88. 326-328 (1999)
“狗失血性休克时肾上腺髓质素的血浆浓度升高” 麻醉
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