Source current density mapping of middle latency response and slow vertex response using a source derivation technique

使用源推导技术的中延迟响应和慢顶点响应的源电流密度映射

• 批准号: 09671776
• 负责人: SHIRAISHI Kimio
• 金额: $ 1.6万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671776/
• 关键词: source derivation; middle latency response; slow vertex response

Source current density (SCD) waveforms were obtained from potential waveforms of the middle latency response (MLR) and slow vertex response (SVR) over the human scalp using a source derivation technique. The SCD waveforms were different from the potential waveforms in the peak latency and polarity. The SCD map of the Pa component in MLR might be composed of more than one generator spatially : the bilateral dipoles in the temporal region and small dipole in the frontal region contralateral to stimulation. The SCD maps of Ni and P2 in SVR suggested bilateral generators in the temporal region as previously reported. However, the two were not identical because of there being a difference in the spatial and temporal patterns between the SCD maps of N1 and P2.By subtracting the SCD waveform from the potential, the low spatial frequency component(LSFC) was obtained. The latencies of both N1 and P2 in the SCD waveform were decreased in comparison to the potential waveform on the scalp. In contrast, the latencies in the LSFC waveform were prolonged. The source region of N1 in the SCD maps appeared initially in the vicinity of the temporal region, contralateral to the stimulated ear, and with time, appeared as restricted source regions in both temporal regions. The maps of P2 in the SCD and LSFC showed a sink region located in both temporal areas, and source regions in the vicinity of the vertex. This P2 sink-source pattern did not change with time.It was concluded that the N1 might be generated from the bilateral temporal regions including contributions from moving deep dipoles. The P2 was thought to originate from an anatomically fixed location in the bilateral temporal sites.

利用源导出技术，从头皮上的中潜伏期反应(MLR)和慢顶反应(SVR)的电位波形中获得源电流密度(SCD)波形。SCD波的峰潜伏期和波极与潜伏期不同。MLR中Pa分量的SCD图在空间上可能由多个发生器组成：刺激对侧的双侧偶极子和额区的小偶极子。SVR中Ni和P2的SCD图表明，如先前报道的那样，在颞区有双侧发生器。然而，由于N1和P2的SCD图在空间和时间模式上存在差异，两者并不相同。通过从电位中减去SCD波形，得到低空间频率分量(LSFC)。与头皮上的电位波形相比，SCD波形中N1和P2潜伏期均缩短。相反，LSFC波形的潜伏期延长。在SCD图中，N1的源区最初出现在刺激耳对侧的颞区附近，随着时间的推移，在两个颞区中都出现了受限源区。在SCD和LSFC的P2图上，汇区位于两个颞区，而源区位于顶点附近。这种P2汇-源模式不随时间变化，推测N1可能来自双侧颞区，包括深偶极子移动的贡献。P2被认为起源于解剖上固定的双侧颞叶部位。