The negative potential auditory brainstem response with a 3msec latency in profoundly deaf patients

重度耳聋患者潜伏期为 3 毫秒的负电位听觉脑干反应

• 批准号: 03807115
• 负责人: SHIRAISHI Kimio
• 金额: $ 0.77万
• 依托单位: FUKUOKA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03807115/
• 关键词: Auditory brainstem response; Profound deafness; Negative potential; Vestibular evoked response

A negative potential at a latency of 3 msecin the auditory brain stem responses (ABRs) was studied in this project from 1991 to 1993. This large negative deflection at the latency of 3 msec was termed the "N3 potential". The results conclusions are summarized as follows.1.The N3 potential was found in 46 cases (6.2%), 57 ears (5.6%) among the 3319 ABR waveforms recorded clinicallyat our departmentfrom 1978 to 1990. The appearance was independent of age and sex.2.The response appeared at the intensity of 80dBnHL or more. As the intensity of stimulationincreased, the amplitude became larger and the latency decreased.3.The N3 potential had was a far-field potential by nature, and a replicability was found in retesting.The patients with the N3 potential had no central disorder. The audiogram showed profound deafness.From the results above, it was suggested that the N3 potential was not an electricalartifact but rather a physiological response to acoustic stimuli. However, the origin of the … More N3 potentialis unknown. It is possibly a vestibularevoked potential, since it occurred in the context of profound or total deafness.Next, the effects of the stimulus repetitionrate and click polarity on the N3 potential were examined and compared with the findings of Wit et al.in pigeons, which concern the vestibular evoked potential from a semicircularcanal to acoustic stimulation.5.The latency remained almost unchanged at 10 to 40/sec.but it was definitely prolonged at 83.3/sec. Also, the amplitude decreased to about one half of that observed at the lower repetition rates. The shortest average latency occurred with the rarefaction click, and the longest with the condensation click.6.No patients with the N3 potential experienced so-called Tullio phenomenon during ABR testing. Furthermore, in one case the ENG failed to show nystagmus in the presence of a loud auditory stimulus.On the basis of these results, the N3 potential was not the same as the vestibular evoked potential from a semicircular canal to acoustic stimulation and was unlikely to be a vestibular evoked potential. However, a saccular acoustic response in the guinea pig after complete cochlear hair cell destruction was observed by Cazals Y and Aran JM.Additionalinvestigations are needed to determine the origin of the N3 potential. Less

本研究于1991 ~ 1993年对听觉脑干反应（ABRs）中潜伏期为3毫秒的负电位进行了研究。在3毫秒的潜伏期，这种巨大的负偏转被称为“N3电位”。结果总结如下：1。在1978 ~ 1990年我科临床记录的3319例ABR波形中，发现N3电位46例（6.2%），57耳（5.6%）。外表与年龄和性别无关。反应出现在80dBnHL及以上。随着刺激强度的增加，振幅变大，潜伏期减小。N3电位本质上是远场电位，在重测中发现了可复制性。N3电位患者无中枢疾病。听力图显示深度耳聋。从以上结果可以看出，N3电位不是一种电伪影，而是一种对声刺激的生理反应。然而，更多潜在的N3的来源是未知的。这可能是前庭诱发电位，因为它发生在深度或完全耳聋的情况下。接下来，我们研究了刺激重复频率和点击极性对N3电位的影响，并与Wit等人在鸽子中的研究结果进行了比较，该研究涉及从半规管到声刺激的前庭诱发电位。延迟几乎保持不变，为10到40/秒。但它确实以83.3秒的速度被延长了。此外，振幅下降到在较低重复频率下观察到的大约一半。稀疏滴答声的平均潜伏期最短，凝结滴答声的平均潜伏期最长。在ABR测试中，没有N3电位患者出现所谓的Tullio现象。此外，在一个病例中，ENG在大声的听觉刺激下没有显示眼球震颤。基于这些结果，N3电位与从半规管到声刺激的前庭诱发电位不相同，不太可能是前庭诱发电位。然而，Cazals Y和Aran JM观察到豚鼠耳蜗毛细胞完全破坏后的囊性声学反应。需要进一步的调查来确定N3势的来源。少

项目成果

白石 君男 他: "音響刺激による潜時3msecの陰性電位ー音刺激間隔と位相との関係についてー" 日本耳鼻咽喉科学会会報. (1992)

Kimio Shiraishi 等人：“由于声刺激而产生 3 毫秒潜伏期的负电势 - 声音刺激间隔与相位之间的关系”日本耳鼻喉科学会通报（1992 年）。

白石君男 他: "音響刺激による潜時3msecの陰性電位-音刺激間隔と位相との関係について" 日本耳鼻咽喉科学会会報. 95. 1638-1639 (1992)

Kimio Shiraishi 等人：“由于声刺激导致的负电位-声音刺激间隔和相位之间的关系，延迟时间为 3 毫秒”，日本耳鼻喉科学会公告 95. 1638-1639 (1992)。

KIMIO SHIRAISHI et al.: "A Negative potential at a latency of 3 msec evoked by acoustic stimulation" J Otolaryngol Jpn. 95. 1638-1639 (1992)

KIMIO SHIRAISHI 等人：“声刺激诱发的潜伏期为 3 毫秒的负电位”J Otolaryngol Jpn。