Effects of inhalation anesthetics on parasympathetic reflex vasodilatation

吸入麻醉药对副交感神经反射性血管舒张的影响

• 批准号: 09671886
• 负责人: IZUMI Hiroshi
• 金额: $ 1.98万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671886/
• 关键词: Inhalation; GABA; Parasympathetic; Vasodilatation; Autonomic; 自律神経

The present experiments were designed to examine the effects of inhalation anesthetics (isoflurane, halothane, and sevoflurane) on the parasympathetic reflex vasodilation in the lower lip and palate elicited by electrical stimulation of the central cut end of the lingual nerve in vago-sympathectomized cats. Isoflurane (1.5%), halothane (1.0 %), sevoflurane (2.5%), each at a concentration of 1.0 MAC (minimum alveolar concentra-tion), markedly suppressed the evoked blood flow increases in the lower lip, whereas nitrous oxide (70 % in 30% oxygen) and morphine (2 mg/kg, iv) did not. Prior administra-tion of picrotoxin, a GABA antagonist, (2 mg/kg, iv) reversed the inhibitory effect of isoflurane on the parasympathetic reflex response. Decerebration had no significant effect on the isoflurane-induced inhibition. These findings suggest that there is a GABA-mediated suppressive mechanism acting on this parasympathetic reflex response ; the sites at which inhalation anesthetics exert such an inhibitory action could be in the mid-brain, pons, or medulla, but not in the hypothalamus or higher structures.

本实验旨在研究吸入麻醉剂（异氟烷，氟烷，七氟烷）的影响，在下唇和腭引起的舌神经的中央切断端的电刺激迷走神经交感神经切除猫的副交感神经反射血管舒张。异氟醚（1.5%）、氟烷（1.0%）、七氟醚（2.5%）（最低肺泡浓度1.0MAC）均能明显抑制诱发的下唇血流量增加，而氧化亚氮（70%）和吗啡（2 mg/kg，iv）则无此作用。预先静脉注射GABA拮抗剂印防己毒素（2 mg/kg）可逆转异氟醚对副交感神经反射的抑制作用。去大脑对异氟烷诱导的抑制作用无显著影响。这些发现表明，有GABA介导的抑制机制作用于这种副交感神经反射反应;吸入麻醉剂发挥这种抑制作用的部位可能在中脑、脑桥或髓质，但不在下丘脑或更高结构。

项目成果

和泉博之: "自律神経研究における麻酔薬選択の重要性" 循環制御. 18. 341-351 (1997)

Hiroyuki Izumi：“麻醉选择在自主神经研究中的重要性”循环控制 18. 341-351 (1997)。

Ito,Y.,Izumi,H.,et al.: "Suppression of parasympathetic reflex vasodilatation in the lower lip of the cat by isoflurane, propofol, ketamine and pentobarbital : implications for mechanisms underlying the production of anaesthesia" Br.J.Anaesthesia. 81. 563

Ito,Y.,Izumi,H.,et al.：“异氟烷、异丙酚、氯胺酮和戊巴比妥抑制猫下唇的副交感神经反射血管舒张：对麻醉产生机制的影响”Br.J.Anaesthesia

Izumi, H.: "Review : Nervous control of blood flow in the orofacial region" Pharmac. Therap.,. 81. 141-161 (1999)

Izumi, H.：“评论：口面部区域血流的神经控制”Pharmac。

Ito, Y., Izumi, H., Sato, M., Karita, K.and Iwatsuki, N.: "Suppression of parasympathetic reflex vasodilatation in the lower lip of the cat by Isoflurane, propofol, ketamine and pentobarbital : implications for mechanisms underlying the production of anae

Ito, Y.、Izumi, H.、Sato, M.、Karita, K. 和 Iwatsuki, N.：“异氟烷、异丙酚、氯胺酮和戊巴比妥抑制猫下唇副交感神经反射血管舒张：对机制的影响

Ito, Y., Izumi, H., et al.: "Suppression of parasympathetic reflex vasodilatation in the lower lip of the cat by isoflurane, propofol, ketamine and pentobarbital : implications for mechanisms underlying the production of anaesthesia" Br.J.Anaesthesia. 81.

Ito, Y.、Izumi, H. 等人：“异氟烷、异丙酚、氯胺酮和戊巴比妥抑制猫下唇的副交感神经反射血管舒张：对麻醉产生机制的影响”Br.J.Anaesthesia