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Correlation between Degree of Inhibition of Parasympathetic Reflex Vasodilation and MAC Value for Various Inhalation Anesthetics

各种吸入麻醉药对副交感反射血管舒张的抑制程度与MAC值的相关性

基本信息

批准号：
09557161
负责人：
IZUMI Hiroshi
金额：
$ 6.72万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09557161/
关键词：
Inhalation GABA Parasympathetic Vasodilatation Autonomic Correlationship 自律神経

项目摘要

The effects of various types of general anesthetics (isoflurane, propofol1 ketamine, pen-tobarbitone) on parasympathetic reflex vasodilatation were compared to investigate the involvement in their actions of GABA-mediated synaptic inhibition, enhancement of which is thought to underlie the action of many anesthetics agents. In urethane plus alpha-chloral-ose anaesthetized cats, parasympathetic reflex vasodilatation in the ipsilateral lower lip was elicited by electrical stimulation of the central cut end of the lingual nerve. Isofluraneand pentobarbitone both produced a marked dose-dependent inhibition of this vasodila-tor response. By contrast, propofol and ketamine had no effect on the parasympathetic reflex vasodilatation. The administration of a GABA-antagonist (picrotoxin) reversed the inhibitions produced by isoflurane (previous results) and pentobarbitone (the presentstudy). A dose-related inhibition of this response was induced by the inhalation anesthetics isoflurane, halothane, sevoflurane, and enflurane, the ID_<50> values being 0.94%, 0.82%, 1.74%, and 2.0%, respectively. These results indicate that the ID_<50> value isapproximately two-thirds of the published MAC value for such anesthetics, suggesting that parasympathetic reflex vasodilation is more susceptible than somato-somatic reflexes to inhibition by inhalation anesthetics.

比较了不同类型的全身麻醉药（异氟烷、丙泊酚、氯胺酮、戊巴比妥）对副交感神经反射血管舒张的影响，以研究其对GABA介导的突触抑制作用的参与，这种抑制作用的增强被认为是许多麻醉药作用的基础。在乌拉坦加α-氯醛-糖麻醉猫，副交感神经反射血管扩张在同侧下唇引起的中央切断端的舌神经的电刺激。异氟醚和戊巴比妥对这种血管舒张反应均产生明显的剂量依赖性抑制作用。而异丙酚和氯胺酮对副交感神经反射性血管舒张无影响。GABA拮抗剂（印防己毒素）的给药逆转了异氟烷（以前的结果）和戊巴比妥（本研究）产生的抑制作用。吸入麻醉药异氟醚、氟烷、七氟醚和安氟醚对该反应的抑制呈剂量依赖性，ID<50>值分别为0.94%、0.82%、1.74%和2.0%。这些结果表明，ID_<50>值约为已发表的MAC值的2/3，表明副交感神经反射血管舒张比躯体反射更容易受到吸入麻醉剂的抑制。