Age-related diseases analyzed by ER stresses and immune functions using murine models including iPSCs

使用包括 iPSC 在内的小鼠模型通过 ER 应激和免疫功能分析年龄相关疾病

• 批准号: 25293166
• 负责人: isobe ken-ichi
• 金额: $ 11.73万
• 依托单位: Nagoya Women's University (2015-2016)Nagoya University (2013-2014)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293166/
• 关键词: 老化; GADD34; ERストレス; ２型糖尿病; 脂肪肝; インスリンシグナル; メタボリックシンドローム; ストレス; 生活習慣病; 免疫; 再生

项目成果

No immunogenicity of IPS cells in syngeneic host studied by in vivo injection and 3D scaffold experiments.

• DOI: 10.1155/2013/378207
• 发表时间: 2013
• 期刊: BioMed research international
• 作者: Thanasegaran S;Cheng Z;Ito S;Nishio N;Isobe K
• 通讯作者: Isobe K

GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation.

• DOI: 10.1038/cddis.2016.116
• 发表时间: 2016-05-12
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Ito S;Tanaka Y;Oshino R;Okado S;Hori M;Isobe KI
• 通讯作者: Isobe KI

iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis.

• DOI: 10.1038/srep01418
• 发表时间: 2013
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Kito, Tetsutaro;Shibata, Rei;Ishii, Masakazu;Suzuki, Hirohiko;Himeno, Tatsuhito;Kataoka, Yoshiyuki;Yamamura, Yumiko;Yamamoto, Takashi;Nishio, Naomi;Ito, Sachiko;Numaguchi, Yasushi;Tanigawa, Tohru;Yamashita, Jun K.;Ouchi, Noriyuki;Honda, Hiroyuki;Isobe, Kenichi;Murohara, Toyoaki
• 通讯作者: Murohara, Toyoaki

Loss of GADD34 induces early age-dependent deviation to the myeloid lineage.

GADD34 的缺失会导致早期年龄依赖性的骨髓谱系偏差。

• DOI: 10.1038/icb.2013.78
• 发表时间: 2013
• 期刊: Immunol Cell Biol.
• 作者: Nishio N;Ito S;Isobe K.
• 通讯作者: Isobe K.

GADD34 works to suppress obesity-induced non alcoholic steatohepatitis (NASH) by regulation of insulin/IGF signaling.

GADD34 通过调节胰岛素/IGF 信号传导来抑制肥胖引起的非酒精性脂肪性肝炎 (NASH)。

• 发表时间: 2014
• 作者: Nishio N;Ito S;Isobe K
• 通讯作者: Isobe K