Development of a novel therapy for pancreatitis through activation of innate immunity

通过激活先天免疫开发胰腺炎新疗法

• 批准号: 25293172
• 负责人: WATANABE TOMOHIRO
• 金额: $ 11.98万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293172/
• 关键词: 膵炎; 自然免疫反応; 自然免疫; NOD1; IL-33; IL-13

项目成果

Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.

• DOI: 10.1016/j.immuni.2012.05.024
• 发表时间: 2012-08-24
• 期刊: Immunity
• 影响因子: 32.4
• 作者: Tsuji Y;Watanabe T;Kudo M;Arai H;Strober W;Chiba T
• 通讯作者: Chiba T

Activation of Toll-like receptors and NOD-like receptors in monocytes and basophils is involved in the immunopathogenesis of IgG4-related disease

单核细胞和嗜碱性粒细胞中 Toll 样受体和 NOD 样受体的激活参与 IgG4 相关疾病的免疫发病机制

• 发表时间: 2014
• 作者: Sun A;Zou Y;Wang P;Xu D;Gong H;Wang S;Qin Y;Zhang P;Chen Y;Harada M;Isse T;Kawamoto T;Fan H;Yang P;Akazawa H;Nagai T;Ping P;Komuro I;Ge J.;Watanabe T;Watanabe T
• 通讯作者: Watanabe T

Mucosal Immunology 4th Edition

粘膜免疫学第四版

• 发表时间: 2015
• 作者: Watanabe T;Chiba T;Strober W
• 通讯作者: Strober W

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

• DOI: 10.1038/mi.2014.19
• 发表时间: 2014-11
• 期刊: Mucosal immunology
• 影响因子: 8