DEEP DRILLING OF THE HUMAN PLASMA PROTEOME

就像熄灭城市灯光一样，你可以更清楚地看到昏暗的星星--从人体生物液中去除高丰度蛋白质可以实现生物标志物发现的巨大飞跃。该项目将开发消除蛋白质组学中最大障碍--高丰度蛋白质(城市灯光)的产品。廉价、高效、常规地去除丰富的蛋白质将放大尖端技术的力量。蛋白质组学技术在发现新的生物标志物中的作用。这是可能的，因为未发现的低拷贝数生物标记物(暗星)存在于人类诊断液中，其水平远远低于当前蛋白质组阵列的检测限值。

Like turning out city lights lets you see the faint stars more clearly - removal of high abundance proteins from human biofluids allows quantum leaps in biomarker discovery. This project will develop products that remove the biggest obstacle in proteomics - high abundance proteins (city lights). Cheap, efficient and routine removal of abundant proteins will amplify the power of ?cutting edge? proteomic technologies in the discovery of novel biomarkers. This is possible because undiscovered low copy number biomarkers (faint stars) exist in human diagnostic fluids at levels far lower than current proteomic array detection limits.