Proteomic and genetic analysis of subfertile bull spermatozoa

不育公牛精子的蛋白质组学和遗传分析

• 批准号: DP190102455
• 负责人: Prof Mark Baker
• 金额: $ 33.15万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102455
• 关键词: Proteomic; genetic; analysis; subfertile; bull

This project aims to identify protein changes on spermatozoa that are highly correlated with the fertility status of bulls. Bull fertility has approached an all-time low as breeding practice has focused predominately on milk production and beef tenderness. This project aims to understand the genetic causes that underpin bull and cattle infertility, and investigate better methods to predict the fertility status of bulls. This project expects to contribute to better clinical management of cattle. This information can then be used for the development of a better diagnostic assay for both the dairy and beef industry.

该项目旨在确定精子上与公牛生育状况高度相关的蛋白质变化。公牛的繁殖力已经接近历史最低水平，因为育种实践主要集中在产奶量和牛肉嫩度上。该项目旨在了解公牛和牛不育的遗传原因，并探索更好的方法来预测公牛的生育状况。该项目预计将有助于更好地对牛进行临床管理。这些信息可以用来开发乳制品和牛肉行业更好的诊断方法。