Studies on Effects of Analgesics in the Central Nervous System Using the Technique of Metabolic Mapping.

利用代谢图谱技术研究镇痛药对中枢神经系统的影响。

• 批准号: 60440073
• 负责人: TAKESHITA Hiroshi
• 金额: $ 5.76万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60440073/
• 关键词: Cerebral Metabolism; Local Cerebral Glucose Utilization; Analgesic

Effects of analgesics in the central nervous system were studied in rats, using the technique of metabolic mapping.Results and Discussion1.Local glucose utilization in the brain and spinal cord was measured after intravenous administration of morphine, 10mg/kg. Compared with glucose utilization in awake rats, metabolism was depressed after morphine administration in the following only 5 of 62 structures studied. Glucose utilization in the interpeduncular nucleus, locus coeruleus, superior oilive nucleus and lateral and ventral white matter in the lumbar spinal cord was decreased by 17-24%. In other structures including periaqueductal gray matter, raphe nuclei, giantocellular reticular nucleus, paragiantocellular nucleus and all layers in the spinal gray matter, glucose utilization remained unchanged.2.Althogh rats showed no responses to noxious stimuli such as pinch of extremities after intravenous administration of morphine, 10mg/kg, electrical stimulation of sciatic nerve induced metabolic activation in the hindlimb projection area in the cerebral cortex. Such metabolic response in the cortex was not observed during deep enflurane anesthesia.3.The local glucose utilization in the spinal cord was measured after epidural administraion of morphine in the lumbar region, which induced analgesia in lower extremities. Epidural morphine does not affect the glucose utilization in any areas of spinal cord compared with that observed in awake rats.

采用代谢图谱技术研究了镇痛药对大鼠中枢神经系统的影响。结果与讨论静脉注射吗啡10mg/kg后，测定脑和脊髓局部葡萄糖利用率。与清醒大鼠的葡萄糖利用相比，吗啡给药后，所研究的62个组织中只有5个组织的代谢受到抑制。髓核间核、蓝斑核、上橄榄核以及腰椎外侧和腹侧白质的葡萄糖利用率下降了17-24%。在其他结构中，包括导水管周围灰质、中缝核、巨细胞网状核、副细胞核和脊髓灰质的所有层，葡萄糖的利用保持不变。大鼠静脉注射10mg/kg吗啡后，针刺四肢等有害刺激无反应，但坐骨神经电刺激引起大脑皮层后肢投射区代谢激活。在深度安氟醚麻醉期间，没有观察到皮层的这种代谢反应。腰区硬膜外给药吗啡后，测定脊髓局部葡萄糖利用情况，诱导下肢镇痛。与清醒大鼠相比，硬膜外吗啡不影响脊髓任何区域的葡萄糖利用。

项目成果

Takeshita H.: "Comparison of epidural morphine and bupivacaine on spinal cord metabolism during sensory stimulation." Anesth. Analg.

Takeshita H.：“硬膜外吗啡和布比卡因在感觉刺激期间对脊髓代谢的影响。”

Nakakimura K.: "Analgesic epidural morphine does not affect local glucose utilization in the spinal cord in rats." Anesth. Analg.

Nakakimura K.：“镇痛硬膜外吗啡不会影响大鼠脊髓中的局部葡萄糖利用。”

中木村和彦: Anesthesia and Analgesia. (1987)

中木村和彦：麻醉与镇痛（1987）。

武下浩: Anesthesia and Analgesia.

竹下浩：麻醉和镇痛。

Takeshita H.: "Local metabolic effects of somatosensory stimulation in the central nersous system of rats given morphine or enflurane." Anesthesiology.

Takeshita H.：“给予吗啡或安氟烷的大鼠中枢神经系统体感刺激的局部代谢效应。”