EFFECTS OF CHRONIC BROMIDE INTOXICATION ON LOCAL CEREBRAL GLUCOSE UTILIZATION

慢性溴化物中毒对局部脑葡萄糖利用的影响

• 批准号: 2447826
• 负责人: L SOKOLOFF
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2447826
• 关键词: brain metabolism; bromine; chronic disease /disorder; deoxyglucose; glucose metabolism; halogen poisoning; laboratory rat; neurotoxicology

Chronic bromide intoxication produces a schizophrenia-like syndrome in man. To determine which structures in brain might be involved, we are studying local cerebral glucose utilization (LCGU) with the [14C]deoxyglucose method in rats being administered bromides chronically in the drinking water for up to 10 days and in both the water and by osmotic pump for up to 49 days. In rats given bromides only in the drinking water serum bromide levels were raised to about 200 mg NaBr/l in 2 days, 400 mg/l in 6 days, and 425 mg/l in 10 days. In control rats given only water serum bromide levels were between 0 and 12.3 mg/l. In rats given bromides in both drinking water and by osmotic pump serum bromide levels averaged 420 mg/l by 14 days, 540 mg/l by 21 days, 540 mg/l by 35 days, and 525 mg/l by 49 days. In control rats serum bromide levels ranged between 0 and 59 mg/l. Average rates of glucose utilization in the brain as a whole have thus far been determined in 34 rats. In rats treated for 21 days with bromide rates of glucose utilization were decreased by 12.5% compared with controls (p<0.05), grouped t-test). Analyses are still being continued and will include local rates of glucose utilization in the brain.

慢性溴化物中毒会导致精神分裂症样综合征， 伙计为了确定大脑中哪些结构可能参与，我们 研究局部脑葡萄糖利用（LCGU）与 大鼠长期给予溴化物的[14 C]脱氧葡萄糖法 在饮用水中长达10天， 渗透泵长达49天。在大鼠中， 饮用水血清溴化物水平升高至约200 mg NaBr/l 在2天，400毫克/升，6天，425毫克/升，10天。对照大鼠中 仅给予水时，血清溴化物水平在0和12.3毫克/升之间。在 在饮用水和渗透泵血清中给予溴化物的大鼠 溴化物水平在14天时平均为420毫克/升，21天时平均为540毫克/升， 35天时为525 mg/l，49天时为525 mg/l。对照组大鼠血清溴 浓度范围为0至59毫克/升。葡萄糖平均利用率 到目前为止，已经在34只大鼠中确定了大脑中的整体水平。大鼠 用溴化物处理21天， 与对照组相比降低12.5%（p<0.05，分组t检验）。 分析仍在继续，将包括当地的 葡萄糖在大脑中的利用。