EFFECTS OF CHRONIC BROMIDE INTOXICATION ON LOCAL CEREBRAL GLUCOSE UTILIZATION

慢性溴化物中毒会产生类似精神分裂症的综合征 为了确定大脑中的哪些结构可能参与其中，我们 研究局部脑葡萄糖利用（LCGU）与 大鼠长期给予溴化物的[14 C]脱氧葡萄糖法 在饮用水中长达10天， 渗透泵长达49天。在大鼠中， 饮用水血清溴化物水平升高至约200 mg NaBr/l 在2天，400毫克/升，6天，425毫克/升，10天。对照大鼠中 仅给予水时，血清溴化物水平在0和12.3毫克/升之间。在 在饮用水和渗透泵血清中给予溴化物的大鼠 溴化物水平在14天时平均为420毫克/升，21天时平均为540毫克/升， 35天时为525 mg/l，49天时为525 mg/l。对照组大鼠血清溴 浓度范围为0至59毫克/升。葡萄糖平均速率 到目前为止，在34年中确定了整个大脑的利用率。 大鼠在大鼠治疗21天溴化率的葡萄糖 利用率比对照组降低12.5%（P<0.05）， 分组t检验）。的光密度分析和图像处理 获得葡萄糖利用率所需的放射自显影， 大脑的个别区域是非常劳动密集型的过程， 因为我们在战争期间遭受了相当大的人员损失， 在过去的两年里，我们被迫暂停了这个项目， 暂时希望。

Chronic bromide intoxication can produce a schizophrenia-like syndrome in man. To determine which structures in brain might be involved, we are studying local cerebral glucose utilization (LCGU) with the [14C]deoxyglucose method in rats being administered bromides chronically in the drinking water for up to 10 days and in both the water and by osmotic pump for up to 49 days. In rats given bromides only in the drinking water serum bromide levels were raised to about 200 mg NaBr/l in 2 days, 400 mg/l in 6 days, and 425 mg/l in 10 days. In control rats given only water serum bromide levels were between 0 and 12.3 mg/l. In rats given bromides in both drinking water and by osmotic pump serum bromide levels averaged 420 mg/l by 14 days, 540 mg/l by 21 days, 540 mg/l by 35 days, and 525 mg/l by 49 days. In control rats serum bromide levels ranged between 0 and 59 mg/l. Average rates of glucose utilization in the brain as a whole have thus far been determined in 34 rats. In rats treated for 21 days with bromide rates of glucose utilization were decreased by 12.5% compared with controls (p<0.05), grouped t-test). Densitometric analyses and image-processing of the autoradiograms needed to obtain rates of glucose utilization in individual regions of the brain are very labor-intensive procedures, and because of the considerable loss of personnel that we suffered during the past two years, we have been compelled to suspend this project, temporarily we hope.