Involvement of the Neuron-Endocrinium in Endogenous Sudden Death

神经元内分泌参与内源性猝死

• 批准号: 60570279
• 负责人: TSUNODA Kenji
• 金额: $ 1.02万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570279/
• 关键词: Heart death; Respiratory death; Adrenocortical hormone; Catecholamine; Cyclic AMP; Cerebral ischemia; Aortic stenosis; ラット; 急死; 心停止先行型急死; 呼吸停止先行型急死; 心不全; コルチコステロン; 突然死

With a view to elucidating the response of stress hormone at sudden death to heart death and respiratory death and using rats, cardiac arrest-preceding type sudden death due to intravenous injection of KCL and apnea-preceding type sudden death due to intravenous injection of SCC were comparatively examined for measured values at agonal stage or immediately after death under condition of the existence or otherwise of such lesions as cerebral ischemia and aortic stenosis with respect to adrenocortical hormone such as corticosterone(CS), catecholamines(CA)[epinephrine(EP), norepinephrine(NE), dopamine(DA)] and cyclic AMP in blood and various organs. In case of the cardiac arrest-precedence or apnea-precedence caused under non-anesthesia in the so-called healthy normal condition without pre-existent lesions, blood CS and CA (EP, NE) showed significantly high values for the latter precedence equivalent to respiratory death; intraadrenal CS and CA (EP, NE, DA) showed significantly low values … More for the latter precedence, intracerebral CA (NE, DA) showed approximate values for both sudden deaths and intramyocardial CA and especially NE showed remarkably low values for respiratory death. In case of cerebral ischemia under non-anes-thesia, blood CS and CA (EP, NE) at sudden death tended to show higher level of values for respiratory death, but with a significant difference for CA; intraadrenal CS showed contrariwise low level of values for respiratory death, CA showed the same level of values for both sudden deaths and intracerebral and intramyocardial CA gave the same results as in healthy normal condition.In case of aortic stenosis as cardiac dysfunction under non-anesthesia, blood CS and CA and intraadrenal CS and CA gave the same results for both sudden deaths as in case of cerebral ischemia; intracerebral CA and especially NE showed slightly high values for respiratory death, an intramyocardial CA gave the same results as in healthy normal condition and in case of cerebral ischemia.Only intramyocardial cyclic AMP showed significantly high level of values for heart death. The above results revealed that the kinetics of stress hormone at sudden death due to cardiac arrest-precedence or apnea-precedence showed remarkably different aspects according to the humoral transmission system and the neural transmission system and depending upon the existence or otherwise of any pre-existent cerebral or cardiac lesion and suggested that quantitative analysis of intraadrenal and intramyocardial stress hormone and its related substance as a clue to the pathogenesis of sudden death made it possible to differentiate heart death from respiratory death. Less

为了阐明猝死时应激激素对心脏死亡和呼吸死亡的反应，心搏骤停--静脉注射氯化钾和呼吸暂停所致的前驱型猝死--对静脉注射SCC引起的前型猝死在濒死期或死亡后即刻在存在或不存在脑缺血等病变的情况下的测量值进行了比较，主动脉狭窄与肾上腺皮质激素如皮质酮（CS）、儿茶酚胺（CA）[肾上腺素（EP）、去甲肾上腺素（NE）、多巴胺（DA）]和血液和各种器官中的环AMP有关。在所谓的健康正常条件下，在无预先存在的病变的非麻醉下引起的心脏骤停优先或呼吸暂停优先的情况下，血液CS和CA（EP，NE）显示出与呼吸死亡相当的后者优先的显著高值;肾上腺内CS和CA（EP，NE，DA）显示出显著低值 ...更多信息 对于后者，脑内CA（NE，DA）显示猝死和心肌内CA的近似值，尤其是NE显示呼吸性死亡的显著低值。在非麻醉状态下脑缺血时，猝死时血CS、CA（EP、NE）有较高的呼吸性死亡值的趋势，但CA有显著性差异;肾上腺内CS显示相反的低水平的呼吸死亡值，对于猝死和脑内和心肌内CA，CA显示相同水平的值，其结果与健康正常情况相同。非麻醉状态下主动脉瓣狭窄引起心功能不全的猝死，血CS、CA和肾上腺内CS、CA与脑缺血猝死的结果相同;脑内CA和尤其是NE显示呼吸死亡的略高值，心肌内CA的结果与正常人和脑缺血时的结果相同，只有心肌内cAMP水平显著升高，心脏死亡的价值上述结果表明，根据体液传递系统和神经传递系统的不同，并取决于是否存在任何前体细胞，心脏骤停优先或呼吸暂停优先猝死时应激激素的动力学表现出明显不同的方面。提示肾上腺内和心肌内应激激素及其相关物质的定量分析可作为判断脑、心损害的线索。猝死的发病机制使心脏性死亡与呼吸性死亡的鉴别成为可能。少

项目成果

Kenji TSUNODA,;Kohichi DOHGE,;Etsuko KASHIMA,et al.: "Experimental Studies on Stress Hormones at the Time of Sudden Death (I) Difference in Adrenocortical Hormone Level between Cardiac Arrest-Preceding Type and Apnea-Preceding Type Sudden Death" Japanese

Kenji Tsunoda,;Kohichi DOHGE,;Etsuko KASHIMA,et al.：“猝死时应激激素的实验研究（I）心脏骤停前型与呼吸暂停前型猝死之间肾上腺皮质激素水平的差异”日语

角田健司,神庭悦子 他: 日本法医学雑誌. 39. 638 (1985)

Kenji Tsunoda、Etsuko Kanba 等人：《日本法医学杂志》39. 638 (1985)。

道解公一,角田健司,賀嶋悦子 他: 日本法医学雑誌. 42. 97 (1988)

Koichi Dokai、Kenji Tsunoda、Etsuko Kashima 等：日本法医学杂志 42. 97 (1988)。

道解公一,角田健司,神庭悦子 他: 日本法医学雑誌. 41. 571 (1987)

Koichi Dokai、Kenji Tsunoda、Etsuko Kanba 等人：日本法医学杂志 41. 571 (1987)。

道解公一,角田健司,神庭悦子 他: 日本法医学雑誌. 41. 138 (1987)

Koichi Dokai、Kenji Tsunoda、Etsuko Kanba 等：日本法医学杂志 41. 138 (1987)。