Effect of dihydrotestosterone on cardiovascular system

我们研究了5 -二氢睾酮（DHT）对心血管系统的影响，包括辅助呼吸作用和循环脂质，使用正常组和肥胖组Wistar阉割雄性大鼠。与对照组相比，激素治疗的正常大鼠右心室壁和心房重量与体重之比显著增加。用参数值乘以心率乘以颈动脉最大收缩压估计的心功能在激素治疗的大鼠中显著降低。然而，在激素治疗的大鼠和对照大鼠之间没有发现右心室活动的差异。在呼吸参数方面，激素处理大鼠呼气CO_2气体明显减少。另一方面，接受激素治疗的肥胖大鼠的心脏重量与体重之比明显增加。这是由于心室间隔重量的显著增加，除了右心室壁和心房的重量增加。激素治疗的肥胖大鼠心脏功能明显低于对照组，也低于正常大鼠。激素处理大鼠呼吸频率明显增加，呼气CO_2气体明显减少。因此，这些结果表明，激素主要对右心室或心房有增厚作用，对心血管功能有抑制作用或对呼吸通气有促进作用，而在肥胖大鼠中，后者的作用相对增强。在血脂方面，与对照组相比，正常组和肥胖组的DHT治疗产生了显著低水平的TC。两组患者均有明显的低水平HDL-C和高水平LDL-C。在两组之间，DHT对HDL-C的影响没有差异，正如在TC的情况下所见。然而，与正常男性相比，肥胖男性对LDL-C水平的影响更大。前者的效价为56.8%，后者为38.6%。对于甘油三酯，两组均发现DHT使血浆水平升高，但与正常男性相比，肥胖男性甘油三酯的效力较低（分别为63.3%和86.7%）。鉴于外源性DHT对肥胖状态下循环LDL-C的显著影响，该激素可能对心血管系统有更不利的影响。少

We conducted a study to evaluate the effects of 5 alpha-dihydrotestosterone (DHT) on the cardiovascular system, including the supplementary respiratory effects, and circulating lipids using normal and obese groups of Wistar castrated male rats. The hormone-treated normal rats had a significantly greater weight of the right ventricular wall and atria and body weight ratio when compared to the controls. Cardiac function estimated from the parametric vaue multiplied heart rate by carotid maximal systolic pressure was significantly lowered in the hormone-treated rats. However, no difference in the right ventricular action between the hormone-treated and control rats was found. In respiratory parameters, expired CO_2 gas decreased significantly in the hormone-treated rats. On the other hand, the hormone-treated obese rats showed a significantly greater weight of the heart and body weight ratio. This was due to the significant gain of the ventricular septum weight, in addition to the weight … More gains of the right ventricular wall and atria. Cardiac function of the hormone-treated obese rats was significantly lower than that of the controls and lower than that of normal rats. Significant increase in respiratory rate and decrease in expired CO_2 gas were seen in the hormone-treated rats. Therefore, these results demonstrate that the hormone had hypertrophic effects mainly on the right ventricle or atria and suppressive effects on cardiovascular function or promotive effects on respiratory ventilation, with both of the latter effects enhanced comparatively in obese rats.Concerning plasma lipids, DHT administration produced a significantly low level of TC in the normal and obese groups, when compared to the controls. A significant low level of HDL-C and a high level of LDL-C were seen in both groups. No difference was observed in the effect of DHT on HDL-C between the groups, as seen in the case of TC.However, the effect on the LDL-C level was greater in obese than in normal males. The potency of the hormone was 56.8% for the former and 38.6% for the latter. For triglycerides, an increase in the plasma level by DHT administration was found in both groups, however, the potency was lower in obese compared to the normal males (63.3% and 86.7%, respectively). In respect of the significant influence of exogenous DHT on circulating LDL-C under an obese state, the hormone may have a more adverse effect on the cardiovascular system. Less