Effect of dihydrotestosterone on cardiovascular system

二氢睾酮对心血管系统的影响

• 批准号: 08670500
• 负责人: TSUNODA Kenji
• 金额: $ 0.26万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670500/
• 关键词: dihydrotestosterone; cardiovascular system; cardiac hypertrophy; hypotension; hyperventilation; obese rats; plasma lipids; LDL-C; 雄性ホルモン; 右室肥大; 循環機能; コレステロール; HDLコレステロール; トリグリセライド; ジハイドロテストステロン; ラット; 心重量; 心室重量; 呼吸機能

We conducted a study to evaluate the effects of 5 alpha-dihydrotestosterone (DHT) on the cardiovascular system, including the supplementary respiratory effects, and circulating lipids using normal and obese groups of Wistar castrated male rats. The hormone-treated normal rats had a significantly greater weight of the right ventricular wall and atria and body weight ratio when compared to the controls. Cardiac function estimated from the parametric vaue multiplied heart rate by carotid maximal systolic pressure was significantly lowered in the hormone-treated rats. However, no difference in the right ventricular action between the hormone-treated and control rats was found. In respiratory parameters, expired CO_2 gas decreased significantly in the hormone-treated rats. On the other hand, the hormone-treated obese rats showed a significantly greater weight of the heart and body weight ratio. This was due to the significant gain of the ventricular septum weight, in addition to the weight … More gains of the right ventricular wall and atria. Cardiac function of the hormone-treated obese rats was significantly lower than that of the controls and lower than that of normal rats. Significant increase in respiratory rate and decrease in expired CO_2 gas were seen in the hormone-treated rats. Therefore, these results demonstrate that the hormone had hypertrophic effects mainly on the right ventricle or atria and suppressive effects on cardiovascular function or promotive effects on respiratory ventilation, with both of the latter effects enhanced comparatively in obese rats.Concerning plasma lipids, DHT administration produced a significantly low level of TC in the normal and obese groups, when compared to the controls. A significant low level of HDL-C and a high level of LDL-C were seen in both groups. No difference was observed in the effect of DHT on HDL-C between the groups, as seen in the case of TC.However, the effect on the LDL-C level was greater in obese than in normal males. The potency of the hormone was 56.8% for the former and 38.6% for the latter. For triglycerides, an increase in the plasma level by DHT administration was found in both groups, however, the potency was lower in obese compared to the normal males (63.3% and 86.7%, respectively). In respect of the significant influence of exogenous DHT on circulating LDL-C under an obese state, the hormone may have a more adverse effect on the cardiovascular system. Less

我们进行了一项研究，以评估5 α-二氢睾酮（DHT）对心血管系统的影响，包括补充呼吸作用，循环脂质使用正常和肥胖组的Wistar去势雄性大鼠。与对照组相比，给予地塞米松的正常大鼠右心室壁和心房的重量以及体重比显著增加。心脏功能估计从参数值乘以心率由颈动脉最大收缩压显着降低，在治疗组大鼠。呼吸参数中，呼出CO_2浓度显著降低，而右心室收缩功能无明显变化。另一方面，经维生素B1治疗的肥胖大鼠显示出显著更大的心脏重量和体重比。这是由于室间隔重量的显著增加，除了重量 ...更多信息 右心室壁和心房的增益。肥胖组大鼠心功能明显低于对照组和正常组。呼吸频率明显增加，呼出CO_2气体减少。因此，这些结果表明，激素主要对右心室或心房的肥大作用和心血管功能的抑制作用或呼吸通气的促进作用，与后两种效果增强相对肥胖rates.Concerning血脂，DHT管理产生了显着低水平的TC在正常和肥胖组相比，与对照组。在两组中均观察到HDL-C水平显著降低和LDL-C水平升高。与TC的情况一样，在两组之间没有观察到DHT对HDL-C的影响差异。然而，肥胖男性对LDL-C水平的影响大于正常男性。激素效价前者为56.8%，后者为38.6%。对于甘油三酯，在两组中均发现DHT给药导致血浆水平升高，然而，与正常男性相比，肥胖男性的效力较低（分别为63.3%和86.7%）。在肥胖状态下外源性DHT对循环LDL-C的显著影响方面，该激素可能对心血管系统具有更不利的影响。少

项目成果

角田 健司: "ラットの心機能に対するアンドロゲン作用" 日本法医学雑誌. 52. 76 (1998)

Kenji Tsunoda：“雄激素对大鼠心脏功能的影响”日本法医学杂志 52. 76 (1998)。