How a ubiquitous endosymbiont of insects protects against pathogens

昆虫普遍存在的内共生体如何防御病原体

• 批准号: DP160100588
• 负责人: Prof Paul Young
• 金额: $ 25.2万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100588
• 关键词: How; ubiquitous; endosymbiont; insects; protects

The project intends to determine the mechanism that underpins pathogen protection in insects. Insects harbour microbial communities in their cells and guts and confer a range of benefits on their hosts. One bacterium, Wolbachia, protects insects against co-infecting pathogens. The release of Wolbachia into mosquito populations is currently being tested as a means to reduce dengue virus transmission to humans. Using innovative evolutionary and genetic approaches, the project proposes to elucidate the mechanism of pathogen blocking and ascertain its broader consequences for the host. This knowledge may be critical for maintaining the effectiveness of the biocontrol approach in the field by informing the development of resistance management strategies.

该项目旨在确定支持昆虫病原体保护的机制。昆虫在它们的细胞和肠道中藏匿微生物群落，并为它们的宿主带来一系列好处。一种名为沃尔巴克氏菌的细菌可以保护昆虫免受共同感染的病原体的侵袭。目前正在测试将沃尔巴克氏菌释放到蚊子种群中，作为减少登革热病毒向人类传播的一种手段。利用创新的进化和遗传方法，该项目建议阐明病原体阻断的机制，并确定其对宿主的更广泛的后果。这一知识可能对通过制定抗性管理战略来维持现场生物防治方法的有效性至关重要。