Strcture Formation of Biological Membranes

生物膜的结构形成

• 批准号: 61302085
• 负责人: MITAKU Shigeki
• 金额: $ 3.97万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61302085/
• 关键词: Biological membrane; Lipid bilayer; Membrane protein; Intramolecular; interaction; Structure formation; Higer order structure

biological membrane is comprised of various kinds of proteins and lipids. However, its structure appears simple, in which lipid bilayer forms the matrix and membrane proteins are embedded in it. The purpose of this project is to investigate the mechanism of the higher order structure of biological membranes from five points of view: (1) Static structure of membrane and lipid bilayer, (2) dynamic structure of membrane, (3) Intramembrane interaction associated with ordered structures, (4) relationship between the structure and the function of membrane proteins, and (5) new techniques studying biological membranes. The results of studies revealed that ordered structures are formed by the balance of electrostatic interaction, hydrogen bonds and hydeophobic interaction and that each interaction plays different role in the ordering phenomena of membrane.

生物膜由各种蛋白质和脂质组成。然而，它的结构看起来很简单，其中脂质双分子层形成基质，膜蛋白嵌入其中。本项目的目的是从五个角度研究生物膜的高级结构的机制：（1）膜和脂双层的静态结构，（2）膜的动态结构，（3）与有序结构相关的膜内相互作用，（4）膜蛋白结构与功能的关系;（5）研究生物膜的新技术。研究结果表明，膜的有序结构是由静电相互作用、氢键和疏水相互作用的平衡而形成的，每种相互作用在膜的有序现象中起着不同的作用。

项目成果

T. Kanemasa; K. Banda; M.Kasai: J. Biochem. (Tokyo). 101. 1025-1032 (1987)

T.兼正；

K. Kinosita; Jr., T. Kouyama; A. lkegami: J. Chem. Phys.86. 3273-3282 (1987)

K.Kinosita；

H. Ohtani; T. Kobayashi; M. Tsuda: Photobiochem. Photobiophys.13. 203-208 (1986)

H.奥塔尼；

角倉一朗: 『音楽芸術』第43巻3号. 43-3. (1985)

门仓一郎：《音乐艺术》第 43 卷，第 3 期。43-3 (1985)

武藤三千夫(共著)石川毅 増伐隆士: "美学芸術教育学" 勁草書房, 247 (1985)

武藤道雄（合著者）石川武和增雪隆：《美学与艺术教育》Keiso Shobo，247（1985）