Study of the function and differentiation of folliculo-stellate cell in anterior pituitary gland.

垂体前叶滤泡星状细胞功能及分化的研究。

• 批准号: 61570003
• 负责人: INOUE Kinji
• 金额: $ 1.34万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570003/
• 关键词: ANTERIOR PITUITARY; STRIATE MUSCLE; FOLLICULO*STELLATE CELL; フィブロネクチン; 筋繊維; ラトケ嚢; 細胞増殖; 分化; カルシウム; S-100蛋白; 機能; ラトケ嚢遺残腔辺縁上皮細胞

In order to reveal the function and differentiation of folliculo-stellate cell in the rat anterior pituitary gland, the morphological studies were performed. The main finding of this study was the observation of striated muscle fibers in the pituitary gland grafts transplanted beneath the kidney capsule. These ectopic differentiated striated muscle fibers were closely associated with folliculo-stellate cells, including the possibility of folliculo-stellate cell have a potential of differentiation to striated muscle fibers.The histochemical studies revealed that follicul/-stellate cell have extremely elongated cell processes which wrap around the neighboring glandular cells. Ca-depend ATPase localized around these cell processes and follicle lumen, suggesting folliculo-stellate cell may control the secretory function of neighboring glandular cells through the regulation of calcium transport. the immunohistochemical studies revealed that folliculo-stellate cell contain fibronectin however, the biological significance of fibronectin in folliculo-stellate cell is unknown.In conclusion, it is considered that folliculo-stellate cell is a multi-functional cell which control the neighboring glandular cell in anterior pituitary gland.

为揭示大鼠垂体前叶滤泡星状细胞的功能和分化，对滤泡星状细胞进行了形态学研究。本研究的主要发现是在肾包膜下移植的垂体移植物中观察到横纹肌纤维。这些异位分化的横纹肌纤维与滤泡-星状细胞密切相关，包括滤泡-星状细胞有向横纹肌纤维分化的可能性，组织化学研究显示滤泡-星状细胞具有极长的细胞突起，包裹在相邻的腺细胞周围。Ca-dependent ATPase定位于这些细胞突起和滤泡腔周围，提示滤泡星状细胞可能通过调节钙转运来控制邻近腺细胞的分泌功能。免疫组化结果显示，滤泡星状细胞中含有纤维连接蛋白，但纤维连接蛋白在滤泡星状细胞中的生物学意义尚不清楚，因此认为滤泡星状细胞是一种多功能细胞，它控制着垂体前叶邻近的腺细胞。

项目成果

Y.C.Liu.: Histochemistry. (1989)

刘永成：组织化学。

LIU Y.C.: "Localization of fibronectin in the folliculo-stellate cells of the rat anterior pituitary by the double bridge peroxidase-antiperoxidase method." Histochemistry. in print. (1989)

刘Y.C.：“通过双桥过氧化物酶-抗过氧化物酶方法定位大鼠垂体前叶滤泡星状细胞中的纤连蛋白。”

井上金治,谷口豊,黒住一昌: 解剖学雑誌. 61. 493-493 (1986)

Kinji Inoue、Yutaka Taniguchi、Kazumasa Kurosumi：解剖学杂志 61. 493-493 (1986)。

井上金治: 病態生理. 8. 75-78 (1989)

井上欣二：病理生理学。8. 75-78 (1989)

INOUE K.: "Regulation of cell proliferation of gonadotrophs in castrated rat anterior pituitary." Proceedings of 8th International Congress of Endocrinology. (1988)

INOUE K.：“去势大鼠垂体前叶促性腺激素细胞增殖的调节。”