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Novel characteristics of ATP as a potential neuro-co-transmitter.

Novel characteristics of ATP as a potential neuro-co-transmitter.
ATP 作为潜在神经递质的新特征。
批准号:
61570114
负责人:
KATSURAGI Takeshi
金额:
$1.28万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1986
资助国家:
日本
项目状态:
已结题
起止时间:
1986 至 1987

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中文摘要
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英文摘要
Recent findings provide evidence that ATP is capable of acting as a neuro-co-transmitter along with the classical transmitter,noradrenaline(NA)in adrenergically dominant tissues.The research project from 1986 to 1987 was designed to clarify further characteristics of cotransmission of NA and ATP from guinea-pig vas deferens.The study with HPLC-ECD in the first year disignated that ouabain(100<micrn>and/or monesin(10<micrn>),but not high KCI,produced a prominent liberation of granular NA which was mediated by intracellular Ca^<2+> originating, presumably,from mitochondrial store sites.In addition to measuring this NA release.the investigation in 1987 was to measure ATP released from the tissue by a lumicounting method in the presence of secretagogues such as ouabain plus monensin and high KCI.Ouabain plus monensin caused a moderate outflow of atp which was markedly diminished by both 6-hydroxydopamine and prazosin,thus,meaning primarily an extraneuronal release of the nucleotide.On the other hand,an outstanding liberation of ATP by high KCI was highly decreased by 6-hydroxydopamine or Ca^<2+>-removal,but not by prazosin,indicating,mainly a neuronal ATP release.Amounts of neuronal release of ATP by ouabain plus monensin and by high KCl were 1.7<micrn>g and 11.2<micrn>g/g wet weight,respectively.On the other hand,that of neuronal release of NA by the same procedures amounted to 7.7<micrn>g and 1.7<micrn>g/g wet weight,respectively.These results strongly support a possibility that NA and ATP are co-released from two different store sites of the adrenergic nerves by depolarization and elevation of intracellular Na^+ levels.
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Takeshi Katsuragi: "Extra and intracellular Ca^<2+>-dependent co-releases of norepinephrine and ATP occur from two different store sites of adrenergic nerve terminals." Journal of Pharmacology and Experimental Therapeutics.
Takeshi Katsuragi:“去甲肾上腺素和 ATP 的细胞外和细胞内 Ca^2 依赖性共同释放发生在肾上腺素能神经末梢的两个不同存储位点。”
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通讯作者:
Toshiro Harada: J.Pharmacol.Exp.Therap.239. 554-558 (1986)
原田敏郎:J.Pharmacol.Exp.Therap.239。
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6
    Identification of a specific transporter on extracellular release of ATP
    • 批准号:
      17590234
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2005
    • 负责人:
      KATSURAGI Takeshi
    • 依托单位:
    Involvement of a transporter in an autocrine / paracrine release of ATP.
    • 批准号:
      15590243
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2003
    • 负责人:
      KATSURAGI Takeshi
    • 依托单位:
    ATP-autocrine/paracrine release and its intracellular Ca^<2+> signals
    • 批准号:
      13670107
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.79万
    • 财政年份:
      2001
    • 负责人:
      KATSURAGI Takeshi
    • 依托单位:
    Possible involvement of CaィイD12+ィエD1-signaling transferred to mitochondria in release of ATP as an autacoid
    • 批准号:
      10670102
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.34万
    • 财政年份:
      1998
    • 负责人:
      KATSURAGI Takeshi
    • 依托单位:
    海外基金