Non-invasive measurement of regional myocardial blood flow
无创测量局部心肌血流量
基本信息
- 批准号:61570404
- 负责人:
- 金额:$ 1.22万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1986
- 资助国家:日本
- 起止时间:1986 至 1987
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
For the purpose of clinical measurement of regional Myocardial blood flow (RMBF),positron emission tomographic (PET) studies were done with ^<13>NH_3 injection metho and C^<13>O_2 inhalation method.(1) ^<13>NH_3 injection method: Serial 6-second PET scanswere performed after the intravenous bolus injection of ^<13>NH_3 in 13 patients with hypertrophic cardiomyopathy (HCM). RMBF was caliculated by first-pass flow model from the following equation RMBF=Cm(T)/ ^T_Ca (<plus-minus>・<rho> ml/min/100g. T is the time when totalfirst-pass arterial concentration has been delivered to myocardium. Ca and Cm is the activity in the arterial blood and the myocardium, respectively. <rho> is the myocardial density. The averaging RMBF in HCM was 64.6(+-)15.9 ml/min/100g, and PMBF in the interventricular septum was significantly lower than in other regions.(2) C^<15>O_2 inhalation method: In this method PET scans were performed in the study state after 8 minutes of inhalation C^<15>O_2 gas. PMBF was caliculated as follows. RMBF=100・<alpha>/<rho> (Ca/Cm-1) ml/min/100g. <alpha> is the decay constant of ^<15>O. RMBF by C^<15>Sd1O_2 method was almost same as the value by ^<13>NH_3 method.
为临床测量局部心肌血流量(RMBF),用NH_3注射法和CO_2吸入法进行正电子发射断层显像(PET)<13><13>。(1)13<13><13>例肥厚型心肌病(HCM)患者静脉注射~(60)NH_3后行连续6秒PET扫描。RMBF=Cm(T)/ ^T_Ca(<plus-minus>·<rho>ml/min/100g. T是总首过动脉浓度输送至心肌的时间。Ca和Cm分别是动脉血和心肌中的活性。<rho>心肌密度。HCM的平均RMBF为64.6(±)15.9 ml/min/100 g,室间隔的PMBF显著低于其他区域。(2)C^<15>O_2吸入法:在研究状态下,吸入C^ O_2气体8分钟后进行PET扫描<15>。PMBF计算如下。RMBF=100·<alpha>/<rho>(Ca/Cm-1)ml/min/100g。<alpha>是^ O的衰变常数<15>。C^Sd1O_2法测定的RMBF<15>值与NH_3法测定的值基本一致<13>。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Katsuya Yoshida et al: European Journal of Nuclear Medicine. 12. 226-230 (1986)
Katsuya Yoshida 等人:《欧洲核医学杂志》。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Yoshida K et al: Eur,J.Nucl,Med.12. 226-230 (1986)
Yoshida K 等人:Eur,J.Nucl,Med.12。
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- 影响因子:0
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- 通讯作者:
Yoshida K. et al: "Fast dynamic study in cardiac positron CT using ^<13>N-ammonia in man" Eur. J. Nucl. Med.12. 226-230 (1986)
Yoshida K.等人:“在人体中使用^ 13 N-氨进行心脏正电子CT的快速动态研究”Eur。
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- 影响因子:0
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MASUDA Yoshiaki其他文献
MASUDA Yoshiaki的其他文献
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{{ truncateString('MASUDA Yoshiaki', 18)}}的其他基金
An Institutional and Empirical Research on Community-based Cooperative Firms in Agriculture,Forestry,Fishery and Others
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Designs of Rural Cooperatives System under the Competition of Corporate Systems
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20380127 - 财政年份:2008
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Experimental study on regeneration of infarcted myocardium by transplantation of cultured self-myoblasts.
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10557066 - 财政年份:1998
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A Research on Transformation of the Federation System of Agricultural Cooperatives in Japan
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08660274 - 财政年份:1996
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