Non-invasive measurement of regional myocardial blood flow

For the purpose of clinical measurement of regional Myocardial blood flow(RMBF)，positron emission tomographic(PET)studies were done with^&lt；13&gt；NH_3injection metho and C^&lt；13&gt；O_2inhalation method.(1)^&lt；13&gt；NH_3injection method：Serial6-second PET scanswere performed after the intravenous bolus injection of^&lt；13&gt；NH_3in13patients h withyproertrophic diomyathy(HCM)。RMBF was caliculated by first-pass flow model from the following@equation RMBF=Cm(T)/^T_Ca(&lt；plus-minus&gt；·&lt；rho&gt；ml/min/100g。T is the time when totalfirst-pass arterial concentration has been delivered to myocardium.Ca and Cm is the activity in the arterial blood and the myocardium，respectively。&lt；rho&gt；is the myocardial density.The averaging RMBF in HCM was#china_person0#.6(+-)15.9ml/min/100g，and PMBF in the interventricular septum was significantly lower than in other regions.(2)C^&lt；15&gt；O_2inhalation method：In this method PET scans were performed in the study state after8minutes of inhalation C^&lt；15&gt；O_2gas.PMBF was caliculated as follows.RMBF=100·&lt；alpha&gt；/&lt；rho&gt；(Ca/Cm-1)ml/min/100g。&lt；alpha&gt；is the decay constant of^&lt；15&gt；O.RMBF by C^&lt；15&gt；Sd1O_2 method was almost same as the value by^&lt；13&gt；NH_3method。

For the purpose of clinical measurement of regional Myocardial blood flow (RMBF),positron emission tomographic (PET) studies were done with ^<13>NH_3 injection metho and C^<13>O_2 inhalation method.(1) ^<13>NH_3 injection method: Serial 6-second PET scanswere performed after the intravenous bolus injection of ^<13>NH_3 in 13 patients with hypertrophic cardiomyopathy (HCM). RMBF was caliculated by first-pass flow model from the following equation RMBF=Cm(T)/ ^T_Ca (<plus-minus>・<rho> ml/min/100g. T is the time when totalfirst-pass arterial concentration has been delivered to myocardium. Ca and Cm is the activity in the arterial blood and the myocardium, respectively. <rho> is the myocardial density. The averaging RMBF in HCM was 64.6(+-)15.9 ml/min/100g, and PMBF in the interventricular septum was significantly lower than in other regions.(2) C^<15>O_2 inhalation method: In this method PET scans were performed in the study state after 8 minutes of inhalation C^<15>O_2 gas. PMBF was caliculated as follows. RMBF=100・<alpha>/<rho> (Ca/Cm-1) ml/min/100g. <alpha> is the decay constant of ^<15>O. RMBF by C^<15>Sd1O_2 method was almost same as the value by ^<13>NH_3 method.