Non-invasive measurement of regional myocardial blood flow

For the purpose of clinical measurement of regional Myocardial blood flow (RMBF),positron emissiontomographic (PET) studies were done with ^<13> nh_3 injection metho and C^<13> o_2 inhalationmethod.(1) ^<13> nh_3 injection method：Serial 6-second PET scanswere performed after the intravenous bolus injection of ^<13> nh_3 in 13patients with hypertrophic cardiomyopathy (HCM) RMBF was caliculated by first-pass flow model fromthe following equation RMBF=Cm(T)/ t_ca (<plus-minus> / <rho> ml/min/100g. T is the time whentotalfirst-pass arterial concentration has been delivered to myocardium. Ca and Cm is the activityin the arterial blood and the myocardiumrespectively. <rho>是myocardial density. averaging RMBF in HCM was 64.6(+-)15.9ml / min / 100 g,与PMBF in the interventricular septum was significantly lower than in其他regions.(2) C^<15> o_2inhalation method:In this method PET scans performed In the study state after 8 minutes of inhalation C <15> o_2gas. PMBF was caliculated as follows. RMBF=100 . <alpha>/<rho> (Ca/Cm-1) ml/min/100g. <alpha> is thedecay constant of ^<15>O. RMBF by C^<15> sd1o_2 method was almost same as the value by ^<13> nh_3method。

For the purpose of clinical measurement of regional Myocardial blood flow (RMBF),positron emission tomographic (PET) studies were done with ^<13>NH_3 injection metho and C^<13>O_2 inhalation method.(1) ^<13>NH_3 injection method: Serial 6-second PET scanswere performed after the intravenous bolus injection of ^<13>NH_3 in 13 patients with hypertrophic cardiomyopathy (HCM). RMBF was caliculated by first-pass flow model from the following equation RMBF=Cm(T)/ ^T_Ca (<plus-minus>・<rho> ml/min/100g. T is the time when totalfirst-pass arterial concentration has been delivered to myocardium. Ca and Cm is the activity in the arterial blood and the myocardium, respectively. <rho> is the myocardial density. The averaging RMBF in HCM was 64.6(+-)15.9 ml/min/100g, and PMBF in the interventricular septum was significantly lower than in other regions.(2) C^<15>O_2 inhalation method: In this method PET scans were performed in the study state after 8 minutes of inhalation C^<15>O_2 gas. PMBF was caliculated as follows. RMBF=100・<alpha>/<rho> (Ca/Cm-1) ml/min/100g. <alpha> is the decay constant of ^<15>O. RMBF by C^<15>Sd1O_2 method was almost same as the value by ^<13>NH_3 method.