ULTRA-COMPACT N-13 AMMONIA GENERATOR FOR PET

适用于宠物的超紧凑型 N-13 氨发生器

• 批准号: 3502293
• 负责人: RUTH E SHEFER
• 金额: $ 5万
• 依托单位: SCIENCE RESEARCH LABORATORY, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3502293
• 关键词: ammonia; biomedical automation; biomedical device power system; biomedical equipment development; clinical biomedical equipment; nitrogen; particle accelerators; positron emission tomography; radiation protection; radiochemistry; radionuclides; radiopharmacology

The objective of this program is to develop a dedicated, accelerator-based 13N-ammonia delivery system for positron emission tomography (PET). 13N- ammonia PET scans can accurately measure myocardial blood flow and have been shown to be valuable tools in diagnosing coronary artery disease. 13N-ammonia can also be utilized to measure blood flow in other parts of the body, including the liver, kidney, brain and malignant tumors. The proposed generator will utilize a very low energy Coaxial Cascade Accelerator (CCA) developed at SRL to produce 13N via the 12C(d,n)13N nuclear reaction. The fully shielded acceleratory and 13N-ammonia production system will be housed in a 1.8 m x 1 m x 1.2 m enclosure and will be fully automated with easily operated push-botton controls. The estimated cost of the 13N-ammonia delivery system is comparable to that of a one of a one year supply of 82 Rb, another commonly used blood flow agent.

该计划的目标是开发一种专用的、基于加速器的 用于正电子发射断层扫描(PET)的13N-氨输送系统。13N- 氨水正电子发射计算机断层扫描可以准确测量心肌血流量，并有 已被证明是诊断冠心病的有价值的工具。 13N-氨也可以用来测量心脏其他部位的血流量。 身体，包括肝、肾、脑和恶性肿瘤。这个 拟建的发电机将采用能量极低的同轴叶栅 SRL开发的加速器(CCA)通过12C(d，n)13N生产13N 核反应。全屏蔽加速器和13N-氨 生产系统将安装在1.8米x 1米x 1.2米的外壳中，并 将是全自动化的，操作简单，按下按钮控制。这个 13N-氨输送系统的估计成本与 一年供应82 RB之一，另一种常用的血流 探员。